Prednisolone Phosphate Sodium
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Hodoodo CAT#: H318565

CAS#: 125-02-0 (Na+ phosphate)

Description: Prednisolone sodium phosphate is a water soluble form of prednisolone, a glucocorticoid. It is used to treat a variety of inflammatory and autoimmune conditions and some cancers. It is the active metabolite of the drug prednisone and is used especially in patients with liver failure, as these individuals are unable to metabolize prednisone into active prednisolone.

Chemical Structure

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Prednisolone Phosphate Sodium
CAS# 125-02-0 (Na+ phosphate)
Instruction

Theoretical Analysis

Hodoodo Cat#: H318565
Name: Prednisolone Phosphate Sodium
CAS#: 125-02-0 (Na+ phosphate)
Chemical Formula: C21H27Na2O8P
Exact Mass: 0.00
Molecular Weight: 484.392
Elemental Analysis: C, 52.07; H, 5.62; Na, 9.49; O, 26.42; P, 6.39

Price and Availability

Size Price Availability Quantity
100g USD -1 2 Weeks
1g USD 150 2 Weeks
2g USD 250 2 Weeks
5g USD 450 2 Weeks
10g USD 750 2 Weeks
20g USD 950 2 Weeks
50g USD 1750 2 Weeks
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Related CAS #: 52-21-1 (acetate)   72064-79-0 (valerate acetate)   630-67-1 (sodium metazoate)   125-02-0 (Na+ phosphate)   50-24-8 (free)  

Synonym: Prednisolone Phosphate Sodium; AKOS016010152; AK115681; prednisolone; sodium phosphate Predsol;Pediapred;

IUPAC/Chemical Name: disodium;[2-[(10R,13S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] phosphate

InChi Key: VJZLQIPZNBPASX-UHFFFAOYSA-L

InChi Code: InChI=1S/C21H29O8P.2Na/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-29-30(26,27)28)20(15,2)10-16(23)18(14)19;;/h5,7,9,14-16,18,23,25H,3-4,6,8,10-11H2,1-2H3,(H2,26,27,28);;/q;2*+1/p-2

SMILES Code: CC12CC(C3C(C1CCC2(C(=O)COP(=O)([O-])[O-])O)CCC4=CC(=O)C=CC34C)O.[Na+].[Na+]

Appearance: White to light yellow solid powder.

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO, not in water 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 484.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Smits EA, Soetekouw JA, van Doormalen I, van den Berg BH, van der Woude MP, de
Wijs-Rot N, Vromans H. Quantitative LC-MS determination of liposomal encapsulated
prednisolone phosphate and non-encapsulated prednisolone concentrations in murine
whole blood and liver tissue. J Pharm Biomed Anal. 2015 Nov 10;115:552-61. doi:
10.1016/j.jpba.2015.07.012. Epub 2015 Jul 26. PubMed PMID: 26319748.

2: Smits EA, Soetekouw JA, Bakker PF, Baijens BJ, Vromans H. Plasma, blood and
liver tissue sample preparation methods for the separate quantification of
liposomal-encapsulated prednisolone phosphate and non-encapsulated prednisolone.
J Liposome Res. 2015 Mar;25(1):46-57. doi: 10.3109/08982104.2014.928887. Epub
2014 Jul 1. PubMed PMID: 24984229.

3: Smits EA, Soetekouw JA, Vromans H. In vitro confirmation of the quantitative
differentiation of liposomal encapsulated and non-encapsulated prednisolone
(phosphate) tissue concentrations by murine phosphatases. J Liposome Res. 2014
Jun;24(2):130-5. doi: 10.3109/08982104.2013.850593. Epub 2013 Nov 5. PubMed PMID:
24188623.

4: Smits EA, Smits CJ, Vromans H. The development of a method to quantify
encapsulated and free prednisolone phosphate in liposomal formulations. J Pharm
Biomed Anal. 2013 Mar 5;75:47-54. doi: 10.1016/j.jpba.2012.11.008. Epub 2012 Nov
21. PubMed PMID: 23312384.

5: Hofkens W, Schelbergen R, Storm G, van den Berg WB, van Lent PL. Liposomal
targeting of prednisolone phosphate to synovial lining macrophages during
experimental arthritis inhibits M1 activation but does not favor M2
differentiation. PLoS One. 2013;8(2):e54016. doi: 10.1371/journal.pone.0054016.
Epub 2013 Feb 28. PubMed PMID: 23468840; PubMed Central PMCID: PMC3585322.

6: Cittadino E, Ferraretto M, Torres E, Maiocchi A, Crielaard BJ, Lammers T,
Storm G, Aime S, Terreno E. MRI evaluation of the antitumor activity of
paramagnetic liposomes loaded with prednisolone phosphate. Eur J Pharm Sci. 2012
Mar 12;45(4):436-41. doi: 10.1016/j.ejps.2011.08.022. Epub 2011 Aug 28. PubMed
PMID: 21896328.

7: Richters CD, Paauw NJ, Mayen I, van Bloois L, Metselaer JM, Storm G, du Pont
JS, Hoekstra MJ, Kreis RW, Kamperdijk EW. Administration of prednisolone
phosphate-liposomes reduces wound contraction in a rat partial-thickness wound
model. Wound Repair Regen. 2006 Sep-Oct;14(5):602-7. PubMed PMID: 17014673.

8: Banciu M, Schiffelers RM, Fens MH, Metselaar JM, Storm G. Anti-angiogenic
effects of liposomal prednisolone phosphate on B16 melanoma in mice. J Control
Release. 2006 Jun 12;113(1):1-8. Epub 2006 Apr 7. PubMed PMID: 16707187.

9: Schiffelers RM, Metselaar JM, Fens MH, Janssen AP, Molema G, Storm G.
Liposome-encapsulated prednisolone phosphate inhibits growth of established
tumors in mice. Neoplasia. 2005 Feb;7(2):118-27. PubMed PMID: 15802017; PubMed
Central PMCID: PMC1501128.

10: Forbes WF. The effect of prednisolone phosphate on the life-span of DBA/2J
mice. Exp Gerontol. 1975 Feb;10(1):27-9. PubMed PMID: 1132444.

11: Benvenuto G, Palumbo E, Marcacci M. [Changes in the blood platelet and
leukocyte count in rabbits treated with
9-alpha-fluoro-16-beta-methyl-prednisolone phosphate disodium salt]. Boll Soc
Ital Biol Sper. 1968 Oct 31;44(20):1696-700. Italian. PubMed PMID: 5721044.

12: BAILEY E, MURPHY D, WEST HF. Oral prednisolone phosphate therapy. Arch Dis
Child. 1963 Feb;38:71-4. PubMed PMID: 13969011; PubMed Central PMCID: PMC2019080.

13: NEW and Nonofficial Drugs; prednisolone phosphate sodium (hydeltrasol). J Am
Med Assoc. 1959 Sep 5;171:51-3. PubMed PMID: 13857325.

14: Banciu M, Metselaar JM, Schiffelers RM, Storm G. Antitumor activity of
liposomal prednisolone phosphate depends on the presence of functional
tumor-associated macrophages in tumor tissue. Neoplasia. 2008 Feb;10(2):108-17.
PubMed PMID: 18283332; PubMed Central PMCID: PMC2244685.

15: Harigai T, Hagiwara H, Ogawa Y, Ishizuka T, Kaneda S, Kimura J. Prednisolone
phosphate-containing TRX-20 liposomes inhibit cytokine and chemokine production
in human fibroblast-like synovial cells: a novel approach to rheumatoid arthritis
therapy. J Pharm Pharmacol. 2007 Jan;59(1):137-43. PubMed PMID: 17227631.

16: Macsai MS, Goel AK, Michael MM, Wall GM, Sternitzke KD, Abshire RL.
Deposition of ciprofloxacin, prednisolone phosphate, and prednisolone acetate in
SeeQuence disposable contact lenses. CLAO J. 1993 Jul;19(3):166-8. PubMed PMID:
8375037.

17: Hobden JA, Engel LS, Hill JM, Callegan MC, O'Callaghan RJ. Prednisolone
acetate or prednisolone phosphate concurrently administered with ciprofloxacin
for the therapy of experimental Pseudomonas aeruginosa keratitis. Curr Eye Res.
1993 May;12(5):469-73. PubMed PMID: 8344070.

18: Mulder CJ, Tytgat GN, Wiltink EH, Houthoff HJ. Comparison of 5-aminosalicylic
acid (3 g) and prednisolone phosphate sodium enemas (30 mg) in the treatment of
distal ulcerative colitis. A prospective, randomized, double-blind trial. Scand J
Gastroenterol. 1988 Oct;23(8):1005-8. PubMed PMID: 3059450.

19: Green K, Downs SJ. Prednisolone phosphate penetration into and through the
cornea. Invest Ophthalmol. 1974 Apr;13(4):316-9. PubMed PMID: 4818819.

20: Bellamy D. Long-term action of prednisolone phosphate on a strain of
short-lived mice. Exp Gerontol. 1968 Dec;3(4):327-33. PubMed PMID: 4237346.