WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H318588
CAS#: 2078-54-8
Description: Propofol is a hypnotic alkylphenol derivative. Propofol is a General Anesthetic. Propofol is a short-acting medication that results in a decreased level of consciousness and lack of memory for events. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA).
Hodoodo Cat#: H318588
Name: Propofol
CAS#: 2078-54-8
Chemical Formula: C12H18O
Exact Mass: 178.14
Molecular Weight: 178.270
Elemental Analysis: C, 80.85; H, 10.18; O, 8.97
Synonym: Propofol; 2,6-DIISOPROPYLPHENOL; Diprivan; Disoprofol; Disoprivan; Fresenius Brand of Propofol ;Fresenius Kabi Brand of Propofol; Fresofol; ICI 35,868; ICI 35868; ICI-35,868; ICI-35868;
IUPAC/Chemical Name: 2,6-di(propan-2-yl)phenol
InChi Key: OLBCVFGFOZPWHH-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H18O/c1-8(2)10-6-5-7-11(9(3)4)12(10)13/h5-9,13H,1-4H3
SMILES Code: CC(C)C1=C(C(=CC=C1)C(C)C)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 178.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lee JH, Kang SH, Kim Y, Kim HA, Kim BS. Effects of propofol-based total
intravenous anesthesia on recurrence and overall survival in patients after
modified radical mastectomy: a retrospective study. Korean J Anesthesiol. 2016
Apr;69(2):126-132. Epub 2016 Mar 30. PubMed PMID: 27066202.
2: Darandale SS, Shevalkar GB, Vavia PR. Effect of Lipid Composition in Propofol
Formulations: Decisive Component in Reducing the Free Propofol Content and
Improving Pharmacodynamic Profiles. AAPS PharmSciTech. 2016 Apr 7. [Epub ahead of
print] PubMed PMID: 27055535.
3: Oh CS, Lee Y, Kang WS, Kim SH. Impact of effect-site concentration of propofol
on cardiac systolic function assessed by tissue Doppler imaging. J Int Med Res.
2016 Apr 5. pii: 0300060516635384. [Epub ahead of print] PubMed PMID: 27048387.
4: Bornkamp JL, Robertson S, Isaza NM, Harrison K, DiGangi BA, Pablo L. Effects
of anesthetic induction with a benzodiazepine plus ketamine hydrochloride or
propofol on hypothermia in dogs undergoing ovariohysterectomy. Am J Vet Res. 2016
Apr;77(4):351-7. doi: 10.2460/ajvr.77.4.351. PubMed PMID: 27027833.
5: White JD, Draganov PV. Adverse events with non-anesthesiologist administration
of propofol: what you see is what you get but getting (the right standard
monitors) is how you see. Endoscopy. 2016 Apr;48(4):405. doi:
10.1055/s-0042-102252. Epub 2016 Mar 29. PubMed PMID: 27022841.
6: Montefiori F, Pawson P, Auckburally A, Scott M, Flaherty D. An evaluation of a
target-controlled infusion of propofol or propofol-alfentanil admixture for
sedation in dogs. J Small Anim Pract. 2016 Apr;57(4):181-7. doi:
10.1111/jsap.12459. PubMed PMID: 27000648.
7: Green SM, Mason KP, Krauss BS. Ketamine and propofol sedation by emergency
medicine specialists: mainstream or menace? Br J Anaesth. 2016 Apr;116(4):449-51.
doi: 10.1093/bja/aew048. PubMed PMID: 26994227.
8: Gemma M, Scola E, Baldoli C, Mucchetti M, Pontesilli S, De Vitis A, Falini A,
Beretta L. Auditory functional magnetic resonance in awake (nonsedated) and
propofol-sedated children. Paediatr Anaesth. 2016 May;26(5):521-30. doi:
10.1111/pan.12884. Epub 2016 Mar 9. PubMed PMID: 26956994.
9: Wang W, Zhou L, Wu LX, Wang T, Zhang CB, Sun L. 5-HT3 Receptor Antagonists for
Propofol Injection Pain: A Meta-Analysis of Randomized Controlled Trials. Clin
Drug Investig. 2016 Apr;36(4):243-53. doi: 10.1007/s40261-016-0375-1. Review.
PubMed PMID: 26860485.
10: Capasso R, Rosa T, Tsou DY, Nekhendzy V, Drover D, Collins J, Zaghi S,
Camacho M. Variable Findings for Drug-Induced Sleep Endoscopy in Obstructive
Sleep Apnea with Propofol versus Dexmedetomidine. Otolaryngol Head Neck Surg.
2016 Apr;154(4):765-70. doi: 10.1177/0194599815625972. Epub 2016 Jan 26. PubMed
PMID: 26814208.
11: Yuan J, Cui G, Li W, Zhang X, Wang X, Zheng H, Zhang J, Xiang S, Xie Z.
Propofol Enhances Hemoglobin-Induced Cytotoxicity in Neurons. Anesth Analg. 2016
Apr;122(4):1024-30. doi: 10.1213/ANE.0000000000001123. PubMed PMID: 26771264.
12: Ansley DM, Raedschelders K, Choi PT, Wang B, Cook RC, Chen DD. Propofol
cardioprotection for on-pump aortocoronary bypass surgery in patients with type 2
diabetes mellitus (PRO-TECT II): a phase 2 randomized-controlled trial. Can J
Anaesth. 2016 Apr;63(4):442-453. Epub 2015 Dec 31. PubMed PMID: 26721648.
13: Gotoda T, Okada H, Hori K, Kawahara Y, Iwamuro M, Abe M, Kono Y, Miura K,
Kanzaki H, Kita M, Kawano S, Yamamoto K. Propofol sedation with a
target-controlled infusion pump and bispectral index monitoring system in elderly
patients during a complex upper endoscopy procedure. Gastrointest Endosc. 2016
Apr;83(4):756-64. doi: 10.1016/j.gie.2015.08.034. Epub 2015 Aug 22. PubMed PMID:
26301406.
14: Cho S, Han JI, Baik HJ, Kim DY, Chun EH. Monitored anesthesia care for great
saphenous vein stripping surgery with target controlled infusion of propofol and
remifentanil: a prospective study. Korean J Anesthesiol. 2016 Apr;69(2):155-160.
Epub 2016 Mar 30. PubMed PMID: 27066207.
15: Stankovski T, Petkoski S, Raeder J, Smith AF, McClintock PV, Stefanovska A.
Alterations in the coupling functions between cortical and cardio-respiratory
oscillations due to anaesthesia with propofol and sevoflurane. Philos Trans A
Math Phys Eng Sci. 2016 May 13;374(2067). pii: 20150186. doi:
10.1098/rsta.2015.0186. PubMed PMID: 27045000.
16: Cattai A, Pilla T, Cagnardi P, Zonca A, Franci P. Evaluation and optimisation
of propofol pharmacokinetic parameters in cats for target-controlled infusion.
Vet Rec. 2016 Apr 4. pii: vetrec-2015-103560. doi: 10.1136/vr.103560. [Epub ahead
of print] PubMed PMID: 27044652.
17: Chen C, Xu GH, Li YH, Tang WX, Wang K. Selective impairment of attention
networks during propofol anesthesia after gynecological surgery in middle-aged
women. J Neurol Sci. 2016 Apr 15;363:126-31. doi: 10.1016/j.jns.2016.02.037. Epub
2016 Feb 17. PubMed PMID: 27000237.
18: Li X, Pan K, Zhu D, Li Y, Tao G. Propofol postsynaptically suppresses
stellate neuron excitability in the entorhinal cortex by influencing the HCN and
TREK-2 channels. Neurosci Lett. 2016 Apr 21;619:54-9. doi:
10.1016/j.neulet.2016.03.014. Epub 2016 Mar 10. PubMed PMID: 26971702.
19: Xu C, Seubert CN, Gravenstein N, Martynyuk AE. Propofol, but not etomidate,
increases corticosterone levels and induces long-term alteration in hippocampal
synaptic activity in neonatal rats. Neurosci Lett. 2016 Apr 8;618:1-5. doi:
10.1016/j.neulet.2016.02.045. Epub 2016 Feb 26. PubMed PMID: 26923669; PubMed
Central PMCID: PMC4818705.
20: Jia L, Wang W, Luo Y, Zhang F, Lu H, Xue Q, Yu B. Inhibition of PARP-1
participates in the mechanisms of propofol-induced amnesia in mice and human.
Brain Res. 2016 Apr 15;1637:137-45. doi: 10.1016/j.brainres.2016.02.031. Epub
2016 Feb 26. PubMed PMID: 26921778.
