Quinestrol
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H318600

CAS#: 152-43-2

Description: Quinestrol is a compound used in estrogen replacement therapy.

Chemical Structure

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Quinestrol
CAS# 152-43-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H318600
Name: Quinestrol
CAS#: 152-43-2
Chemical Formula: C25H32O2
Exact Mass: 364.24
Molecular Weight: 364.520
Elemental Analysis: C, 82.37; H, 8.85; O, 8.78

Price and Availability

Size Price Availability Quantity
5g USD -1 2 Weeks
10g USD -1 2 Weeks
100mg USD 250 2 Weeks
200mg USD 450 2 Weeks
500mg USD 650 2 Weeks
1g USD 950 2 Weeks
2g USD 1450 2 Weeks
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Synonym: Quinestrol; Estrovis; Quinestrolum; Estrovister; Plestrovis; Eston; Ethinyl; Estradiol 3 Cyclopentyl Ether; Ethinyl Estradiol 3-Cyclopentyl Ether; Parke Davis Brand of Quinestrol ;Quinestrol;

IUPAC/Chemical Name: (8R,9S,13S,14S,17R)-3-cyclopentyloxy-17-ethynyl-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-ol

InChi Key: PWZUUYSISTUNDW-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H32O2/c1-3-25(26)15-13-23-22-10-8-17-16-19(27-18-6-4-5-7-18)9-11-20(17)21(22)12-14-24(23,25)2/h1,9,11,16,18,21-23,26H,4-8,10,12-15H2,2H3

SMILES Code: CC12CCC3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)OC5CCCC5

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO and ethanol

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 364.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li J, Chen F, Chen Y, Wang Z. Mitochondrial- and Fas-L-mediated pathways
involved in quinestrol induced spermatogenic apoptosis in adult rat testes.
Toxicol Mech Methods. 2014 Dec;24(9):609-15. doi: 10.3109/15376516.2014.970680.
Epub 2014 Oct 10. Review. PubMed PMID: 25258304.


2: Li J, Chen F, Li C, Chen Y. Quinestrol induces spermatogenic apoptosis in vivo
via increasing pro-apoptotic proteins in adult male mice. Tissue Cell. 2014
Oct;46(5):318-25. doi: 10.1016/j.tice.2014.05.012. Epub 2014 Jun 27. PubMed PMID:
25038589.


3: Geng Q, Li P, Zhang W, Deng Y, Duan Y, Cao Y. The bioaccumulation and
biotransformation of synthetic estrogen quinestrol in crucian carp. Aquat
Toxicol. 2014 Oct;155:84-90. doi: 10.1016/j.aquatox.2014.06.011. Epub 2014 Jun
24. PubMed PMID: 24997302.


4: Li J, Wang H, Zhang J, Zhou B, Si L, Wei L, Li X. Abnormal secretion of
reproductive hormones and antioxidant status involved in quinestrol-induced
reproductive toxicity in adult male rat. Tissue Cell. 2014 Feb;46(1):27-32. doi:
10.1016/j.tice.2013.09.002. Epub 2013 Oct 1. PubMed PMID: 24183492.


5: Zhang Q, Wang C, Liu W, Qu J, Liu M, Zhang Y, Zhao M. Degradation of the
potential rodent contraceptive quinestrol and elimination of its estrogenic
activity in soil and water. Environ Sci Pollut Res Int. 2014 Jan;21(1):652-9.
doi: 10.1007/s11356-013-1941-1. Epub 2013 Jul 2. PubMed PMID: 23818077.


6: Fu H, Zhang J, Shi D, Wu X. Effects of levonorgestrel-quinestrol (EP-1)
treatment on Mongolian gerbil wild populations: a case study. Integr Zool. 2013
Sep;8(3):277-84. doi: 10.1111/1749-4877.12018. PubMed PMID: 24020466.


7: Wang DW, Ouyang CB, Liu Q, Yuan HL, Liu XH. Inclusion of quinestrol and
2,6-di-O-methyl-β-cyclodextrin: Preparation, characterization, and inclusion
mode. Carbohydr Polym. 2013 Apr 2;93(2):753-60. doi:
10.1016/j.carbpol.2012.12.007. Epub 2012 Dec 12. PubMed PMID: 23499120.


8: Liu Q, Qin J, Chen Q, Wang D, Shi D. Fertility control of Rattus nitidus using
quinestrol: effects on reproductive organs and social behavior. Integr Zool. 2013
Apr;8 Suppl 1:9-17. doi: 10.1111/j.1749-4877.2012.00296.x. Epub 2012 Oct 31.
PubMed PMID: 23621467.


9: Lv X, Guo Y, Shi D. Effects of quinestrol and levonorgestrel on prolactin
serum concentration in lactating Mongolian gerbils (Meriones unguiculatus) and
reproductive parameters of their offspring. Reprod Biol. 2012 Nov;12(3):285-92.
doi: 10.1016/j.repbio.2012.09.005. Epub 2012 Oct 17. PubMed PMID: 23153699.


10: Tang T, Qian K, Shi T, Wang F, Li P, Li J, Cao Y. Photodegradation of
quinestrol in waters and the transformation products by UV irradiation.
Chemosphere. 2012 Nov;89(11):1419-25. doi: 10.1016/j.chemosphere.2012.06.011.
Epub 2012 Jul 5. PubMed PMID: 22771000.


11: Shen W, Shi D, Wang D, Guo Y. Inhibitive effects of quinestrol on male testes
in Mongolian gerbils (Meriones unguiculatus). Res Vet Sci. 2012 Oct;93(2):907-13.
doi: 10.1016/j.rvsc.2011.10.010. Epub 2011 Dec 5. PubMed PMID: 22153020.


12: Lv X, Guo Y, Shi D. Effects of quinestrol on reproductive hormone expression,
secretion, and receptor levels in female Mongolian gerbils (Meriones
unguiculatus). Theriogenology. 2012 Apr 1;77(6):1223-31. doi:
10.1016/j.theriogenology.2011.10.030. Epub 2012 Jan 26. PubMed PMID: 22284225.


13: Liu M, Qu J, Yang M, Wang Z, Wang Y, Zhang Y, Zhang Z. Effects of quinestrol
and levonorgestrel on populations of plateau pikas, Ochotona curzoniae, in the
Qinghai-Tibetan Plateau. Pest Manag Sci. 2012 Apr;68(4):592-601. doi:
10.1002/ps.2302. Epub 2012 Jan 9. PubMed PMID: 22232019.


14: Liu M, Wan X, Yin Y, Li YX, Sun F, Zhang Z, Wang YL. Subfertile effects of
quinestrol and levonorgestrel in male rats. Reprod Fertil Dev.
2012;24(2):297-308. doi: 10.1071/RD10221. PubMed PMID: 22281075.


15: Lv X, Shi D. Combined effects of levonorgestrel and quinestrol on
reproductive hormone levels and receptor expression in females of the Mongolian
gerbil (Meriones unguiculatus). Zoolog Sci. 2012 Jan;29(1):37-42. doi:
10.2108/zsj.29.37. PubMed PMID: 22233494.


16: Wang D, Li N, Liu M, Huang B, Liu Q, Liu X. Behavioral evaluation of
quinestrol as a sterilant in male Brandt's voles. Physiol Behav. 2011 Oct
24;104(5):1024-30. doi: 10.1016/j.physbeh.2011.06.024. Epub 2011 Jul 7. PubMed
PMID: 21763706.


17: Lv XH, Shi DZ. Effects of quinestrol as a contraceptive in mongolian gerbils
(Meriones unguiculatus). Exp Anim. 2011;60(5):489-96. PubMed PMID: 22041286.


18: Shen W, Shi D, Wand D, Guo Y, Hai S, Yue Z. Quinestrol treatment induced
testicular damage via oxidative stress in male Mongolian gerbils (Meriones
unguiculatus). Exp Anim. 2011;60(5):445-53. PubMed PMID: 22041281.


19: Tang T, Li P, Luo L, Shi D, Li J, Cao Y. Development and validation of a HPLC
method for determination of levonorgestrel and quinestrol in rat plasma. Biomed
Chromatogr. 2010 Jul;24(7):706-10. doi: 10.1002/bmc.1350. PubMed PMID: 19882745.


20: Löw O, Grimm S. Morphometric investigations on endocrine glands. VIII.
Karyometry in epithelial cells of thyroid glands during inhibition of lactation
by quinestrol. Exp Toxicol Pathol. 1992 Jun;44(3):141-3. PubMed PMID: 1504578.