Quinine (free base)
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Hodoodo CAT#: H318603

CAS#: 130-95-0 (free base)

Description: Quinine (free base) is an optical isomer of Quinidine and an anti-malarial, skeletal, muscle relaxant.


Chemical Structure

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Quinine (free base)
CAS# 130-95-0 (free base)

Theoretical Analysis

Hodoodo Cat#: H318603
Name: Quinine (free base)
CAS#: 130-95-0 (free base)
Chemical Formula: C20H24N2O2
Exact Mass: 324.18
Molecular Weight: 324.420
Elemental Analysis: C, 74.04; H, 7.46; N, 8.64; O, 9.86

Price and Availability

Size Price Availability Quantity
2g USD 250 2 weeks
5g USD 390 2 weeks
10g USD 520 2 weeks
20g USD 750 2 weeks
50g USD 950 2 weeks
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Related CAS #: 60-93-5 (2HCl)   6119-70-6 (sulfate dihydrate)   804-63-7 (sulfate)   130-95-0 (free base)   60-93-5 (2HCl)   6119-70-6 (sulfate dihydrate)   804-63-7 (sulfate)   130-95-0 (free base)   549-49-5 (HBr)  

Synonym: Quinine (free base); Chinin; Chininum; 6'-Methoxycinchonidine; (8S,9R)-Quinine; Qualaquin; Odan Brand of Quinine Sulfate; Plough Brand of Quinine Sulfate; Prosana Brand of Quinine Bisulfate; Quinamm; Quinbisan; Quinbisul; Quindan;

IUPAC/Chemical Name: (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol

InChi Key: LOUPRKONTZGTKE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3

SMILES Code: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in Ethanol, DMSO, and DMF

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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Bureau: Marketing Practices and Knowledge Circulation in a Dutch Transoceanic
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abandon quinine plus antibiotic for treating uncomplicated falciparum malaria? A
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the Disposition of Quinine in Healthy Volunteers After Concurrent Ciprofloxacin
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9: Burger RJ, van Eijk AM, Bussink M, Hill J, Ter Kuile FO. Artemisinin-Based
Combination Therapy Versus Quinine or Other Combinations for Treatment of
Uncomplicated Plasmodium falciparum Malaria in the Second and Third Trimester of
Pregnancy: A Systematic Review and Meta-Analysis. Open Forum Infect Dis. 2015 Nov
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Quinine-Based Zwitterionic Chiral Stationary Phase as a Complementary Tool for
Peptide Analysis: Mobile Phase Effects on Enantio- and Stereoselectivity of
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calorimeter for screening bitterness-suppressing molecules of quinine. Food Chem.
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14: González Reyes AB, Hardisson de la Torre A, Gutiérrez Fernández AJ, Rubio
Armendáriz C, Frías Tejera I, Revert Gironés C. [CAFFEINE AND QUININE IN SOFT
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15: Babalonis S, Hampson AJ, Lofwall MR, Nuzzo PA, Walsh SL. Quinine as a
potential tracer for medication adherence: A pharmacokinetic and pharmacodynamic
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16: Liles NW, Page EE, Liles AL, Vesely SK, Raskob GE, George JN. Diversity and
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17: Yang S, Shen LL, Kim YJ, Jeong JH. Effective and novel enantioselective
preparation of pyranopyrazoles and pyranocoumarins that is catalyzed by a
quinine-derived primary amine. Org Biomol Chem. 2016 Jan 14;14(2):623-30. doi:
10.1039/c5ob01656h. PubMed PMID: 26540619.


18: Wang SW, Yang SG, Liu W, Zhang YX, Xu PX, Wang T, Ling TJ, Liu RT.
Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing
beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice
with Alzheimer's disease. Behav Brain Res. 2016 Jan 1;296:109-17. doi:
10.1016/j.bbr.2015.09.003. Epub 2015 Sep 7. PubMed PMID: 26358659.


19: Zhou D, Huang Z, Yu X, Wang Y, Li J, Wang W, Xie H. A Quinine-Squaramide
Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Cyclic Trifluoromethyl
Ketimines with Naphthols and Electron-Rich Phenols. Org Lett. 2015 Nov
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Na-Bangchang K. Pharmacokinetic Interactions Between Quinine and
Lopinavir/Ritonavir in Healthy Thai Adults. Am J Trop Med Hyg. 2015
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26416104; PubMed Central PMCID: PMC4674263.