NSC59984
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H407327

CAS#: 803647-40-7

Description: NSC59984 is a p53 pathway activator. NSC59984 restores wild-type p53 signaling via p73 activation, specifically in mutant p53-expressing colorectal cancer cells. NSC59984 synergizes with CPT11 to induce cell death in mutant p53-expressing colorectal cancer cells and inhibits mutant p53-associated colon tumor xenograft growth in a p73-dependent manner in vivo. NSC59984 as a promising lead compound for anticancer therapy that acts by targeting GOF-mutant p53 and stimulates p73 to restore the p53 pathway signaling.

Chemical Structure

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NSC59984
CAS# 803647-40-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H407327
Name: NSC59984
CAS#: 803647-40-7
Chemical Formula: C12H15N3O4
Exact Mass: 265.11
Molecular Weight: 265.269
Elemental Analysis: C, 54.33; H, 5.70; N, 15.84; O, 24.12

Price and Availability

Size Price Availability Quantity
100mg USD 450 2 Weeks
200mg USD 850 2 Weeks
500mg USD 1750 2 Weeks
1g USD 2950 2 Weeks
2g USD 4750 2 Weeks
5g USD 6950 2 Weeks
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Synonym: NSC59984; NSC-59984; NSC 59984.

IUPAC/Chemical Name: (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one

InChi Key: QKTRIGNWBRHBFV-DUXPYHPUSA-N

InChi Code: InChI=1S/C12H15N3O4/c1-13-6-8-14(9-7-13)11(16)4-2-10-3-5-12(19-10)15(17)18/h2-5H,6-9H2,1H3/b4-2+

SMILES Code: O=C(N1CCN(C)CC1)/C=C/C2=CC=C([N+]([O-])=O)O2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 265.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhang S, Zhou L, Hong B, van den Heuvel AP, Prabhu VV, Warfel NA, Kline CL,
Dicker DT, Kopelovich L, El-Deiry WS. Small-Molecule NSC59984 Restores p53
Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73
Activation and Degradation of Mutant p53. Cancer Res. 2015 Sep 15;75(18):3842-52.
doi: 10.1158/0008-5472.CAN-13-1079. Epub 2015 Aug 20. PubMed PMID: 26294215;
PubMed Central PMCID: PMC4573895.


(last updated: 4/20/2016)