WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526617
CAS#: 349085-82-1
Description: GSK137647A is an agonist of the free fatty acid receptor 4 (FFA4/GPR120) with pEC50s = 6.3, 6.2, and 6.1 at human, mouse, and rat receptors, respectively. GSK137647A is selective for GPR120 over a panel of 61 other targets, including other FFARs.
Hodoodo Cat#: H526617
Name: GSK137647A
CAS#: 349085-82-1
Chemical Formula: C16H19NO3S
Exact Mass: 305.11
Molecular Weight: 305.392
Elemental Analysis: C, 62.93; H, 6.27; N, 4.59; O, 15.72; S, 10.50
Synonym: GSK137647A; GSK-137647A; GSK 137647A; GSK137647; GSK-137647; GSK 137647.
IUPAC/Chemical Name: 4-methoxy-N-(2,4,6-trimethylphenyl)-benzenesulfonamide
InChi Key: FQUAFMNPXPXOJE-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
SMILES Code: O=S(C1=CC=C(OC)C=C1)(NC2=C(C)C=C(C)C=C2C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 305.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, Jenkinson S,
Laudeman C, Leesnitzer MA, Liang X, Maloney P, McCoy DC, Moncol D, Rash V, Rimele
T, Vulimiri P, Way JM, Ross S. Identification of diarylsulfonamides as agonists
of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014 Jul
15;24(14):3100-3. doi: 10.1016/j.bmcl.2014.05.012. Epub 2014 May 16. PubMed PMID:
24881566.