AMG-0347

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H524208

CAS#: 946615-43-6

Description: AMG-0347 has analgesic effects of a recently developed transient receptor potential vanilloid 1 (TRPV1) antagonist. The effect of either AMG0347 or morphine was tested for its effects on guarding pain score, heat withdrawal latency, and mechanical withdrawal threshold.


Chemical Structure

img
AMG-0347
CAS# 946615-43-6

Theoretical Analysis

Hodoodo Cat#: H524208
Name: AMG-0347
CAS#: 946615-43-6
Chemical Formula: C24H26F3N3O2
Exact Mass: 445.20
Molecular Weight: 445.480
Elemental Analysis: C, 64.71; H, 5.88; F, 12.79; N, 9.43; O, 7.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AMG-0347; AMG 0347; AMG0347; UNII-CD7L9290QR;

IUPAC/Chemical Name: 2-Propenamide, 3-(2-(1-piperidinyl)-6-(trifluoromethyl)-3-pyridinyl)-N-(5,6,7,8-tetrahydro-7-hydroxy-1-naphthalenyl)-, (2E)-

InChi Key: YCDWBIUKUBHSKQ-FMIVXFBMSA-N

InChi Code: InChI=1S/C24H26F3N3O2/c25-24(26,27)21-11-8-17(23(29-21)30-13-2-1-3-14-30)9-12-22(32)28-20-6-4-5-16-7-10-18(31)15-19(16)20/h4-6,8-9,11-12,18,31H,1-3,7,10,13-15H2,(H,28,32)/b12-9+

SMILES Code: c1cc2c(c(c1)NC(=O)/C=C/c3ccc(nc3N4CCCCC4)C(F)(F)F)CC(CC2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 445.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Garami A, Pakai E, Oliveira DL, Steiner AA, Wanner SP, Almeida MC, Lesnikov VA, Gavva NR, Romanovsky AA. Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis. J Neurosci. 2011 Feb 2;31(5):1721-33. doi: 10.1523/JNEUROSCI.4671-10.2011. PubMed PMID: 21289181; PubMed Central PMCID: PMC3430466.

2: Wu C, Gavva NR, Brennan TJ. Effect of AMG0347, a transient receptor potential type V1 receptor antagonist, and morphine on pain behavior after plantar incision. Anesthesiology. 2008 Jun;108(6):1100-8. doi: 10.1097/ALN.0b013e31817302b3. PubMed PMID: 18497612.

3: Montell C, Caterina MJ. Thermoregulation: channels that are cool to the core. Curr Biol. 2007 Oct 23;17(20):R885-7. Review. PubMed PMID: 17956748.

4: Steiner AA, Turek VF, Almeida MC, Burmeister JJ, Oliveira DL, Roberts JL, Bannon AW, Norman MH, Louis JC, Treanor JJ, Gavva NR, Romanovsky AA. Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors. J Neurosci. 2007 Jul 11;27(28):7459-68. PubMed PMID: 17626206.