WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524423
CAS#: 142654-34-0
Description: BMS 180680 is antibacterial activity agent of new catechol-containing monobactam. BMS-180680 is often the most active compound against many species of the family Enterobacteriaceae, with MICs at which 90% of the isolates were inhibited.
Hodoodo Cat#: H524423
Name: BMS 180680
CAS#: 142654-34-0
Chemical Formula: C19H17N7O10S2
Exact Mass: 567.05
Molecular Weight: 567.510
Elemental Analysis: C, 40.21; H, 3.02; N, 17.28; O, 28.19; S, 11.30
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Synonym: BMS 180680; BMS180680; BMS-180680; SQ 84,100;
IUPAC/Chemical Name: 3-((((1-(2-Amino-4-thiazolyl)-2-((2-methyl-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)methyl)-6,7-dihydroxy-2-quinoxalinecarboxylic acid (2R-(2alpha,3alpha(Z)))-
InChi Key: FAUHVXXXXAHABE-ZOUYLLLXSA-N
InChi Code: InChI=1S/C19H17N7O10S2/c1-6-13(17(30)26(6)38(33,34)35)24-16(29)14(10-5-37-19(20)23-10)25-36-4-9-15(18(31)32)22-8-3-12(28)11(27)2-7(8)21-9/h2-3,5-6,13,27-28H,4H2,1H3,(H2,20,23)(H,24,29)(H,31,32)(H,33,34,35)/b25-14-/t6-,13+/m0/s1
SMILES Code: n1c(c(nc2cc(c(cc12)O)O)CO\N=C(/C(=O)N[C@@H]1[C@@H](N(C1=O)S(=O)(=O)O)C)c1nc(sc1)N)C(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 567.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Schwan WR, Barker L, Brody LL. Differences in sensitivity to PA-1806 among iron transport mutants of Pseudomonas aeruginosa compared to Escherichia coli. Antimicrob Agents Chemother. 2000 Nov;44(11):3237-8. PubMed PMID: 11184229; PubMed Central PMCID: PMC101644.
2: Jagota NK, Chetram AJ, Nair JB. Determination of trace levels of hydrazine in the penultimate intermediate of a novel anti-infective agent. J Pharm Biomed Anal. 1998 Feb;16(6):1083-7. PubMed PMID: 9547713.
3: Fung-Tomc J, Bush K, Minassian B, Kolek B, Flamm R, Gradelski E, Bonner D. Antibacterial activity of BMS-180680, a new catechol-containing monobactam. Antimicrob Agents Chemother. 1997 May;41(5):1010-6. PubMed PMID: 9145861; PubMed Central PMCID: PMC163842.
