WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524539
CAS#: 17730-82-4 (HCl)
Description: Bucinnazine is a potent and selective agonist of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. Bucinnazine was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of piperazine-amides first synthesized and reported in Japan in the 1970s. Bucinnazine has analgesic potency comparable to that of morphine but with a relatively higher therapeutic index.
Hodoodo Cat#: H524539
Name: Bucinnazine HCl
CAS#: 17730-82-4 (HCl)
Chemical Formula: C17H25ClN2O
Exact Mass: 308.17
Molecular Weight: 308.850
Elemental Analysis: C, 66.11; H, 8.16; Cl, 11.48; N, 9.07; O, 5.18
Related CAS #: 17719-89-0 (free base) 17730-82-4 (HCl)
Synonym: Bucinnazine Hydrochloride; Bucinnazine HCl; AP 237; AP-237, AP-237 HCl
IUPAC/Chemical Name: (E)-1-(4-cinnamylpiperazin-1-yl)butan-1-one hydrochloride
InChi Key: HPGCBEMVWCCLIT-AAGWESIMSA-N
InChi Code: InChI=1S/C17H24N2O.ClH/c1-2-7-17(20)19-14-12-18(13-15-19)11-6-10-16-8-4-3-5-9-16;/h3-6,8-10H,2,7,11-15H2,1H3;1H/b10-6+;
SMILES Code: CCCC(N1CCN(C/C=C/C2=CC=CC=C2)CC1)=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Bucinnazine was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that bucinnazine has a marked reinforcing effect with tolerance and dependence quickly developing. In addition, the morphine antagonist naloxone reverses the effect of bucinnazine and precipitates withdrawal symptoms in bucinnazine treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors. (source: https://en.wikipedia.org/wiki/Bucinnazine)
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The following data is based on the product molecular weight 308.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
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