Bucinnazine HCl
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Hodoodo CAT#: H524539

CAS#: 17730-82-4 (HCl)

Description: Bucinnazine is a potent and selective agonist of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. Bucinnazine was widely used in China to treat pain in cancer patients as of 1986. It is one of the most potent compounds among a series of piperazine-amides first synthesized and reported in Japan in the 1970s. Bucinnazine has analgesic potency comparable to that of morphine but with a relatively higher therapeutic index.


Chemical Structure

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Bucinnazine HCl
CAS# 17730-82-4 (HCl)

Theoretical Analysis

Hodoodo Cat#: H524539
Name: Bucinnazine HCl
CAS#: 17730-82-4 (HCl)
Chemical Formula: C17H25ClN2O
Exact Mass: 308.17
Molecular Weight: 308.850
Elemental Analysis: C, 66.11; H, 8.16; Cl, 11.48; N, 9.07; O, 5.18

Price and Availability

Size Price Availability Quantity
1mg USD 350 2 Weeks
5mg USD 750 2 Weeks
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Related CAS #: 17719-89-0 (free base)   17730-82-4 (HCl)    

Synonym: Bucinnazine Hydrochloride; Bucinnazine HCl; AP 237; AP-237, AP-237 HCl

IUPAC/Chemical Name: (E)-1-(4-cinnamylpiperazin-1-yl)butan-1-one hydrochloride

InChi Key: HPGCBEMVWCCLIT-AAGWESIMSA-N

InChi Code: InChI=1S/C17H24N2O.ClH/c1-2-7-17(20)19-14-12-18(13-15-19)11-6-10-16-8-4-3-5-9-16;/h3-6,8-10H,2,7,11-15H2,1H3;1H/b10-6+;

SMILES Code: CCCC(N1CCN(C/C=C/C2=CC=CC=C2)CC1)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info: Bucinnazine was initially claimed to be a non-narcotic analgesic. However, subsequent studies have shown bucinnazine and similar acyl piperazines to be potent and selective agonists of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor. In accordance with these studies, results from the intravenous self-administration experiments in rats showed that bucinnazine has a marked reinforcing effect with tolerance and dependence quickly developing. In addition, the morphine antagonist naloxone reverses the effect of bucinnazine and precipitates withdrawal symptoms in bucinnazine treated rats further indicating a mechanism of analgesia mediated via selective agonist activity at μ-opioid receptors. (source: https://en.wikipedia.org/wiki/Bucinnazine)

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 308.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ma T, Yu Y, Cao H, Wang H, Wang M. Effect of Intermittent Thoracic Paravertebral Block on Postoperative Nausea and Vomiting Following Thoracoscopic Radical Resection of the Lung Cancer: A Prospective Randomized Trial. J Pain Res. 2024 Mar 7;17:931-939. doi: 10.2147/JPR.S453615. PMID: 38469556; PMCID: PMC10926915.


2: Gao ZM, Shi JY, Zeng H, Zhang XJ. Rapid Determination of Bucinnazine in Blood by UPLC-MS/MS. Fa Yi Xue Za Zhi. 2023 Aug 25;39(4):388-392. English, Chinese. doi: 10.12116/j.issn.1004-5619.2022.320702. PMID: 37859478.


3: Pelletier R, Bourdais A, Fabresse N, Ferron PJ, Morel I, Gicquel T, Le Daré B. In silico and in vitro metabolism studies of the new synthetic opiate AP-237 (bucinnazine) using bioinformatics tools. Arch Toxicol. 2024 Jan;98(1):165-179. doi: 10.1007/s00204-023-03617-x. Epub 2023 Oct 15. PMID: 37839054.


4: Resnik KN, Babb KN, Bekenstein LW, Moeller FG, Peace MR, Alves EA. Case report: Identification of AP-238 and 2-fluorodeschloroketamine in internet available powder samples sold as bucinnazine. Forensic Sci Int. 2023 Jul;348:111732. doi: 10.1016/j.forsciint.2023.111732. Epub 2023 May 18. PMID: 37216788.


5: Resnik K, Brandão P, Alves EA. DARK Classics in Chemical Neuroscience: Bucinnazine. ACS Chem Neurosci. 2021 Oct 6;12(19):3527-3534. doi: 10.1021/acschemneuro.1c00522. Epub 2021 Sep 16. PMID: 34528782.


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8: Ping Y, Jing C, Qing J. Comparison of the use of different analgesics in the course of anesthesia care based on pharmacoeconomics. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2241-2247. PMID: 30463819.


9: Zhang C, Han SQ, Zhao H, Lin S, Hasi WL. Detection and Quantification of Bucinnazine Hydrochloride Injection Based on SERS Technology. Anal Sci. 2018 Nov 10;34(11):1249-1255. doi: 10.2116/analsci.18P158. Epub 2018 Jul 6. PMID: 29984780.


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