CO-102862
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H524765

CAS#: 181144-66-1

Description: CO-102862, also known as V102862, is a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. It is an orally active anticonvulsant with robust activity in a variety of rodent models of epilepsy.

Chemical Structure

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CO-102862
CAS# 181144-66-1
Instruction

Theoretical Analysis

Hodoodo Cat#: H524765
Name: CO-102862
CAS#: 181144-66-1
Chemical Formula: C14H12FN3O2
Exact Mass: 273.09
Molecular Weight: 273.260
Elemental Analysis: C, 61.53; H, 4.43; F, 6.95; N, 15.38; O, 11.71

Price and Availability

Size Price Availability Quantity
10mg USD 320 2 Weeks
50mg USD 1035 2 Weeks
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Synonym: CO-102862; CO 102862; CO102862; UNII-0KN11H90GF; V-102862.

IUPAC/Chemical Name: 2-((4-(4-Fluorophenoxy)phenyl)methylene)hydrazinecarboxamide

InChi Key: MHUUDVZSPFRUSK-RQZCQDPDSA-N

InChi Code: InChI=1S/C14H12FN3O2/c15-11-3-7-13(8-4-11)20-12-5-1-10(2-6-12)9-17-18-14(16)19/h1-9H,(H3,16,18,19)/b17-9+

SMILES Code: c1cc(ccc1/C=N/NC(=O)N)Oc2ccc(cc2)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 273.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Ilyin VI, Hodges DD, Whittemore ER, Carter RB, Cai SX, Woodward RM. V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Br J Pharmacol. 2005 Mar;144(6):801-12. PubMed PMID: 15778702; PubMed Central PMCID: PMC1576061.

2: Ramu K, Lam GN, Chien B. Development of a high-performance liquid chromatographic-tandem mass spectrometric method for the determination of pharmacokinetics of Co 102862 in mouse, rat, monkey and dog plasma. J Chromatogr B Biomed Sci Appl. 2000 Nov 10;749(1):1-15. PubMed PMID: 11129068.

3: Dimmock JR, Semple HA, John S, Beazely MA, Abrams GD. Isolation and identification of the major urinary metabolite of 4-(4-fluorophenoxy)benzaldehyde semicarbazone after oral dosing to rats. Pharmazie. 1999 Apr;54(4):260-2. PubMed PMID: 10234738.