WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H406763
CAS#: 1361415-84-0 (free base); 1361415-86-2 (HCl).
Description: AC410 is a potent, selective, orally-administered, small molecule inhibitor of Janus kinase 2 (JAK2, Kd = 0.18 nM) and has potential utility in autoimmune and inflammatory indications. Activity data: the specificity of AC410 for JAK2 vis-a-vis JAK1 (Kd = 2.5 nM) and JAK3 (Kd = 5 nM).
Hodoodo Cat#: H406763
Name: AC410
CAS#: 1361415-84-0 (free base); 1361415-86-2 (HCl).
Chemical Formula: C19H16FN5O
Exact Mass: 349.13
Molecular Weight: 349.369
Elemental Analysis: C, 65.32; H, 4.62; F, 5.44; N, 20.05; O, 4.58
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Synonym: AC410; AC-410; AC 410.
IUPAC/Chemical Name: (S)-(4-fluorophenyl)(4-((5-methyl-1H-pyrazol-3-yl)amino)quinazolin-2-yl)methanol
InChi Key: DCRWIATZWHLIPN-KRWDZBQOSA-N
InChi Code: InChI=1S/C19H16FN5O/c1-11-10-16(25-24-11)22-18-14-4-2-3-5-15(14)21-19(23-18)17(26)12-6-8-13(20)9-7-12/h2-10,17,26H,1H3,(H2,21,22,23,24,25)/t17-/m0/s1
SMILES Code: O[C@@H](C1=CC=C(F)C=C1)C2=NC(NC3=NNC(C)=C3)=C4C=CC=CC4=N2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 349.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. http://ayurajan.blogspot.com/2015/09/drugs-in-clinical-pipeline-ac410.html
2. Holladay, M. W.; et. al. An optically active pyrazolylaminoquinazoline, and pharmaceutical compositions and methods of use thereof. WO2012030917A1