WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526689
CAS#: 169679-53-2
Description: T-0201, also known as TA 0201, is a highly potent, long-lasting, orally active and selective ETA receptor antagonist.. In binding studies, T-0201 competitively antagonized the specific binding of [125I]-ET-1 to human cloned ETA receptors (the Ki value was 0.015 +/- 0.004 nM). T-0201 weakly inhibited [125I]-ET-1-binding to human cloned ETB receptors; the Ki value was 41 +/- 21 nM. T-0201 also caused the inhibition of ET-1-induced contraction of the isolated rabbit pulmonary artery (pA2 = 5.7 +/- 0.3).
Hodoodo Cat#: H526689
Name: T-0201
CAS#: 169679-53-2
Chemical Formula: C27H28BrN5O5S
Exact Mass: 613.10
Molecular Weight: 614.515
Elemental Analysis: C, 52.77; H, 4.59; Br, 13.00; N, 11.40; O, 13.02; S, 5.22
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Related CAS #: 169679-53-2 188307-16-6 (sodium salt)
Synonym: T-0201, T0201, T 0201, TA 0201, TA0201, TA-0201
IUPAC/Chemical Name: N-(6-(2-((5-bromopyrimidin-2-yl)oxy)ethoxy)-5-(p-tolyl)pyrimidin-4-yl)-4-(1-hydroxy-2-methylpropan-2-yl)benzenesulfonamide
InChi Key: YAWNVAQKVARTGQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C27H28BrN5O5S/c1-18-4-6-19(7-5-18)23-24(33-39(35,36)22-10-8-20(9-11-22)27(2,3)16-34)31-17-32-25(23)37-12-13-38-26-29-14-21(28)15-30-26/h4-11,14-15,17,34H,12-13,16H2,1-3H3,(H,31,32,33)
SMILES Code: CC(CO)(C)C1=CC=C(S(NC2=NC=NC(OCCOC3=NC=C(Br)C=N3)=C2C4=CC=C(C)C=C4)(=O)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 614.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |