WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526693
CAS#: 169545-27-1
Description: IRL-2500 is a potent and selective endothelin-B receptor antagonist. IRL-2500 inhibited the binding of [125I]-endothelin-1 (ET-1) to human ETB (IC50 1.3 +/- 0.2 nM) and ETA (IC50 94 +/- 3 nM) receptors expressed in transfected Chinese hamster ovary (CHO) cells. In in vitro studies, IRL 2500 inhibited the sarafotoxin S6c (STX6c)-mediated contraction of the dog saphenous vein (pKb 7.77) and the STX6c-induced relaxation of the preconstricted rabbit mesenteric artery (pKb 6.92). IRL 2500 also attenuated the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat.
Hodoodo Cat#: H526693
Name: IRL-2500
CAS#: 169545-27-1
Chemical Formula: C36H35N3O4
Exact Mass: 573.26
Molecular Weight: 573.693
Elemental Analysis: C, 75.37; H, 6.15; N, 7.32; O, 11.16
Synonym: IRL-2500; IRL 2500; IRL2500.
IUPAC/Chemical Name: ((R)-3-([1,1'-biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan
InChi Key: UZDORQWMYRRLQV-JHOUSYSJSA-N
InChi Code: InChI=1S/C36H35N3O4/c1-23-17-24(2)19-28(18-23)35(41)39(3)33(20-25-13-15-27(16-14-25)26-9-5-4-6-10-26)34(40)38-32(36(42)43)21-29-22-37-31-12-8-7-11-30(29)31/h4-19,22,32-33,37H,20-21H2,1-3H3,(H,38,40)(H,42,43)/t32-,33+/m0/s1
SMILES Code: O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)[C@H](N(C(C3=CC(C)=CC(C)=C3)=O)C)CC4=CC=C(C=C4)C5=CC=CC=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 573.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bergdahl A, Valdemarsson S, Adner M, Sun XY, Hedner T, Edvinsson L. Enhanced
endothelin-1-induced contractions in mesenteric arteries from rats with
congestive heart failure: role of ET(B) receptors. Eur J Heart Fail. 2001
Jun;3(3):293-9. PubMed PMID: 11377999.
2: Macchia M, Barontini S, Ceccarelli F, Galoppini C, Giusti L, Hamdan M,
Lucacchini A, Martinelli A, Menchini E, Mazzoni MR, Revoltella RP, Romagnoli F,
Rovero P. Toward the rational development of peptidomimetic analogs of the
C-terminal endothelin hexapeptide: development of a theoretical model. Farmaco.
1998 Aug-Sep;53(8-9):545-56. PubMed PMID: 10081817.
3: Russell FD, Davenport AP. Characterization of the binding of endothelin ETB
selective ligands in human and rat heart. Br J Pharmacol. 1996 Oct;119(4):631-6.
PubMed PMID: 8904635; PubMed Central PMCID: PMC1915765.