WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524818
CAS#: 121584-61-0
Description: CP 81282 inhibits human renin and endothiapepsin.
Hodoodo Cat#: H524818
Name: CP 81282
CAS#: 121584-61-0
Chemical Formula: C32H47F2N5O6
Exact Mass: 635.35
Molecular Weight: 635.740
Elemental Analysis: C, 60.46; H, 7.45; F, 5.98; N, 11.02; O, 15.10
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: CP 81282; CP81282; CP-81282; CP-81,282.
IUPAC/Chemical Name: L-Norleucinamide, N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-(1-(cyclohexylmethyl)-3,3-difluoro-4-(methylamino)-2,4-dioxobutyl)-, (S)-
InChi Key: UASBNVCJGQKXON-GSDHBNRESA-N
InChi Code: InChI=1S/C32H47F2N5O6/c1-3-4-15-24(36-25(20-22-11-7-5-8-12-22)27(40)32(33,34)30(43)35-2)28(41)38-29(42)26(21-23-13-9-6-10-14-23)37-31(44)39-16-18-45-19-17-39/h6,9-10,13-14,22,24-26,36H,3-5,7-8,11-12,15-21H2,1-2H3,(H,35,43)(H,37,44)(H,38,41,42)/t24-,25-,26-/m0/s1
SMILES Code: CCCC[C@@H](C(=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)N2CCOCC2)N[C@@H](CC3CCCCC3)C(=O)C(C(=O)NC)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 635.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Aguilar CF, Cronin NB, Badasso M, Dreyer T, Newman MP, Cooper JB, Hoover DJ, Wood SP, Johnson MS, Blundell TL. The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae. J Mol Biol. 1997 Apr 11;267(4):899-915. PubMed PMID: 9135120.
2: Badasso M, Wood SP, Aguilar C, Cooper JB, Blundell TL, Dreyer T. Crystallization and preliminary crystallographic characterization of aspartic proteinase-A from baker's yeast and its complexes with inhibitors. J Mol Biol. 1993 Jul 20;232(2):701-3. PubMed PMID: 8345528.
3: Veerapandian B, Cooper JB, Sali A, Blundell TL, Rosati RL, Dominy BW, Damon DB, Hoover DJ. Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases. Protein Sci. 1992 Mar;1(3):322-8. PubMed PMID: 1304340; PubMed Central PMCID: PMC2142209.
4: Hoover DJ, Veerapandian B, Cooper JB, Damon DB, Dominy BW, Rosati RL, Blundell TL. X-ray analysis of a difluorostatone renin inhibitor bound as the tetrahedral hydrate to the aspartic protease endothiapepsin. Adv Exp Med Biol. 1991;306:269-73. PubMed PMID: 1812716.