WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524857
CAS#: 331727-55-0
Description: CP-608039 is a selective adenosine A3 receptor agonist with 1,260-fold selectivity for the human A3 versus human A1 receptor.
Hodoodo Cat#: H524857
Name: CP-608039
CAS#: 331727-55-0
Chemical Formula: C23H25ClN8O5
Exact Mass: 528.16
Molecular Weight: 528.950
Elemental Analysis: C, 52.23; H, 4.76; Cl, 6.70; N, 21.18; O, 15.12
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Synonym: CP-608039; CP608039; CP 608039; UNII-A1LB8I4247.
IUPAC/Chemical Name: beta-D-Ribofuranuronamide, 3-amino-1-(6-(((5-chloro-2-((3-methyl-5-isoxazolyl)methoxy)phenyl)methyl)amino)-9H-purin-9-yl)-1,3-dideoxy-N-methyl-
InChi Key: PKUZHLZHLVHAIO-QYUDBREXSA-N
InChi Code: InChI=1S/C23H25ClN8O5/c1-11-5-14(37-31-11)8-35-15-4-3-13(24)6-12(15)7-27-20-17-21(29-9-28-20)32(10-30-17)23-18(33)16(25)19(36-23)22(34)26-2/h3-6,9-10,16,18-19,23,33H,7-8,25H2,1-2H3,(H,26,34)(H,27,28,29)/t16-,18+,19-,23+/m0/s1
SMILES Code: CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1N)n2cnc3c(NCc4cc(Cl)ccc4OCc5onc(C)c5)ncnc23
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 528.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tracey WR, Magee WP, Oleynek JJ, Hill RJ, Smith AH, Flynn DM, Knight DR. Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury. Am J Physiol Heart Circ Physiol. 2003 Dec;285(6):H2780-7. Epub 2003 Aug 14. PubMed PMID: 12919933.
2: DeNinno MP, Masamune H, Chenard LK, DiRico KJ, Eller C, Etienne JB, Tickner JE, Kennedy SP, Knight DR, Kong J, Oleynek JJ, Tracey WR, Hill RJ. 3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor. J Med Chem. 2003 Jan 30;46(3):353-5. PubMed PMID: 12540233.