WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H524887
CAS#: 41177-35-9
Description: CS 476 is an oral hypoglycaemic agent.
Hodoodo Cat#: H524887
Name: CS 476
CAS#: 41177-35-9
Chemical Formula: C24H29N3O5S
Exact Mass: 471.18
Molecular Weight: 471.570
Elemental Analysis: C, 61.13; H, 6.20; N, 8.91; O, 16.96; S, 6.80
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Synonym: CS 476; CS-476; CS476; NOVO CS 476; NSC 302998.
IUPAC/Chemical Name: N-(4-(2-(2,3-Dihydrobenzo(b)furan-7-carboxamido)ethyl)benzenesulfonyl)-N'-cyclohexylurea
InChi Key: RNQMWIVFHOCVMM-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H29N3O5S/c28-23(21-8-4-5-18-14-16-32-22(18)21)25-15-13-17-9-11-20(12-10-17)33(30,31)27-24(29)26-19-6-2-1-3-7-19/h4-5,8-12,19H,1-3,6-7,13-16H2,(H,25,28)(H2,26,27,29)
SMILES Code: S(NC(NC1CCCCC1)=O)(c1ccc(CCNC(c2c3OCCc3ccc2)=O)cc1)(=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
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The following data is based on the product molecular weight 471.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ma M, Dai Y, Zou JL, Wang L, Pan K, Fu HG. Synthesis of iron oxide/partly graphitized carbon composites as a high-efficiency and low-cost cathode catalyst for microbial fuel cells. ACS Appl Mater Interfaces. 2014 Aug 27;6(16):13438-47. doi: 10.1021/am501844p. Epub 2014 Aug 14. PubMed PMID: 25084054.
2: Taylor T, Gotfredsen C, Chasseaud LF, Elsom LF, Franklin ER. Disposition of the hypoglycaemic sulphonylurea CS 476. Acta Pharmacol Toxicol (Copenh). 1977 Jul;41(1):25-32. PubMed PMID: 578376.
3: Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-7-carboxamid o)-ethyl)-benzenesulphonyl]-N'-cyclohexlurea (NOVO CS 476). III. General pharmacological studies. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):234-40. PubMed PMID: 402792.
4: Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo(b)furan-m-carboxamido)-ethyl)-benzenesulphonyl]-N'-cycl ohexylurea (NOVO CS 476). I. Pharmacological studies on the hypoglycaemic effect. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):216-26. PubMed PMID: 402791.
5: Jorgensen KD. The pharmacology of a new hypoglycaemic agent N-[4-(2-(2,3-dihydrobenzo (b) furan-7-carboxamido)-ethyl)-benzenesulphonyl]-N'-cyclohexylurea (NOVO CS 476). II. Pharmacological studies on the mechanism of action. Acta Pharmacol Toxicol (Copenh). 1977 Feb;40(2):227-33. PubMed PMID: 190857.
