WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H406772
CAS#: 331244-89-4
Description: BAM 7 is a Bax activator (EC50 = 3.3 μM). BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in cancer.
Hodoodo Cat#: H406772
Name: BAM 7
CAS#: 331244-89-4
Chemical Formula: C21H19N5O2S
Exact Mass: 405.13
Molecular Weight: 405.476
Elemental Analysis: C, 62.21; H, 4.72; N, 17.27; O, 7.89; S, 7.91
Synonym: BAM 7; BAM-7; BAM7.
IUPAC/Chemical Name: (E)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one
InChi Key: KOCVKGYKBLJEPK-LYBHJNIJSA-N
InChi Code: InChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
SMILES Code: O=C(N(C1=NC(C2=CC=CC=C2)=CS1)N=C/3C)C3=N\NC4=CC=CC=C4OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 405.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD. Direct and
selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012
Jul;8(7):639-45. doi: 10.1038/nchembio.995. Epub 2012 May 27. PubMed PMID:
22634637; PubMed Central PMCID: PMC3617124.
