F15845 HBr

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H556140

CAS#: 866760-23-8 (HBr)

Description: F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters such as basal cardiac function, hemodynamic functions and ventricular fibrillation. F15845 was also shown to exert improved effects when the membrane potential was depolarized,[1] by acting on the extracellular side of the channel.

Chemical Structure

img
F15845 HBr
CAS# 866760-23-8 (HBr)
Instruction

Theoretical Analysis

Hodoodo Cat#: H556140
Name: F15845 HBr
CAS#: 866760-23-8 (HBr)
Chemical Formula: C20H26BrNO2S2
Exact Mass: 0.00
Molecular Weight: 456.457
Elemental Analysis: C, 52.63; H, 5.74; Br, 17.51; N, 3.07; O, 7.01; S, 14.05

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 470454-73-0 (free base)   866760-23-8 (HBr)   470454-74-1 (fumarate)    

Synonym: F15845 HBr; F15845 hydrobromide; F15845; F-15845; F 15845;

IUPAC/Chemical Name: (S)-N-((S)-3-((2-methoxyphenyl)thio)-2-methylpropyl)-3,4-dihydro-2H-benzo[b][1,4]oxathiepin-3-amine hydrobromide

InChi Key: CUWFVJMNULNBTG-MOGJOVFKSA-N

InChi Code: InChI=1S/C20H25NO2S2.BrH/c1-15(13-24-19-9-5-3-7-17(19)22-2)11-21-16-12-23-18-8-4-6-10-20(18)25-14-16;/h3-10,15-16,21H,11-14H2,1-2H3;1H/t15-,16-;/m0./s1

SMILES Code: C[C@H](CSC1=CC=CC=C1OC)CN[C@H]2COC3=CC=CC=C3SC2.[H]Br

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 456.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Antzelevitch C, Nesterenko V, Shryock JC, Rajamani S, Song Y, Belardinelli L. The role of late I Na in development of cardiac arrhythmias. Handb Exp Pharmacol. 2014;221:137-68. doi: 10.1007/978-3-642-41588-3_7. PMID: 24737235; PMCID: PMC4076160.


2: Bocquet A, Sablayrolles S, Vacher B, Le Grand B. F 15845, a new blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. Br J Pharmacol. 2010 Sep;161(2):405-15. doi: 10.1111/j.1476-5381.2010.00912.x. PMID: 20735424; PMCID: PMC2989591.


3: Pignier C, Rougier JS, Vié B, Culié C, Verscheure Y, Vacher B, Abriel H, Le Grand B. Selective inhibition of persistent sodium current by F 15845 prevents ischaemia-induced arrhythmias. Br J Pharmacol. 2010 Sep;161(1):79-91. doi: 10.1111/j.1476-5381.2010.00884.x. PMID: 20718741; PMCID: PMC2962818.


4: Létienne R, Bel L, Bessac AM, Vacher B, Le Grand B. Myocardial protection by F 15845, a persistent sodium current blocker, in an ischemia-reperfusion model in the pig. Eur J Pharmacol. 2009 Dec 10;624(1-3):16-22. doi: 10.1016/j.ejphar.2009.09.032. Epub 2009 Sep 22. PMID: 19778535.


5: Vié B, Sablayrolles S, Létienne R, Vacher B, Darmellah A, Bernard M, Feuvray D, Le Grand B. 3-(R)-[3-(2-methoxyphenylthio-2-(S)-methylpropyl]amino-3,4-dihydr o-2H-1,5-benzoxathiepine bromhydrate (F 15845) prevents ischemia-induced heart remodeling by reduction of the intracellular Na+ overload. J Pharmacol Exp Ther. 2009 Sep;330(3):696-703. doi: 10.1124/jpet.109.153122. Epub 2009 Jun 10. PMID: 19515969.


6: Vacher B, Pignier C, Létienne R, Verscheure Y, Le Grand B. F 15845 inhibits persistent sodium current in the heart and prevents angina in animal models. Br J Pharmacol. 2009 Jan;156(2):214-25. doi: 10.1111/j.1476-5381.2008.00062.x. Epub 2009 Jan 7. PMID: 19133985; PMCID: PMC2697839.


7: Saint DA. Persistent (current) in the face of adversity ... a new class of cardiac anti-ischaemic compounds on the horizon? Br J Pharmacol. 2009 Jan;156(2):211-3. doi: 10.1111/j.1476-5381.2008.00077.x. Epub 2009 Jan 7. PMID: 19133984; PMCID: PMC2697828.