WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525002
CAS#: 361343-20-6(Elzasonan Citrate) ; 220322-05-4 (Elzasonan hydrochloride)
Description: Elzasonan citrate is a selective 5-HT1B and 5-HT1D receptor antagonist for the treatment of depression. By preferentially blocking 5-HT1B and 5-HT1D autoreceptors, Elzasonan is thought to enhance serotonergic innervations originating from the raphe nucleus, thereby improving signaling to limbic regions like the hippocampus and prefrontal cortex and ultimately resulting in antidepressant effects.
Hodoodo Cat#: H525002
Name: Elzasonan citrate
CAS#: 361343-20-6(Elzasonan Citrate) ; 220322-05-4 (Elzasonan hydrochloride)
Chemical Formula: C28H31Cl2N3O8S
Exact Mass: 0.00
Molecular Weight: 640.530
Elemental Analysis: C, 52.50; H, 4.88; Cl, 11.07; N, 6.56; O, 19.98; S, 5.01
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Synonym: Elzasonan citrate; CP-448,187-10;UNII-67JE11VN82; Elzasonan citrate [USAN].
IUPAC/Chemical Name: (2Z)-4-(3,4-dichlorphenyl)-2-(2-(4-methylpiperazin-1-yl)benzylidene)thiomorpholin-3-one citrate (1:1)
InChi Key: FIXQLYVNGQBUAP-UXTSPRGOSA-N
InChi Code: InChI=1S/C22H23Cl2N3OS.C6H8O7/c1-25-8-10-26(11-9-25)20-5-3-2-4-16(20)14-21-22(28)27(12-13-29-21)17-6-7-18(23)19(24)15-17;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-7,14-15H,8-13H2,1H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b21-14-;
SMILES Code: CN1CCN(CC1)c2ccccc2\C=C\3/SCCN(C3=O)c4ccc(Cl)c(Cl)c4.OC(=O)CC(O)(CC(=O)O)C(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 640.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kamel A, Colizza K, Obach RS. In vitro metabolism of the 5-hydroxytryptamine1B receptor antagonist elzasonan. Xenobiotica. 2013 Apr;43(4):368-78. doi: 10.3109/00498254.2012.723150. Epub 2012 Oct 3. PubMed PMID: 23030680.
2: Kamel A, Obach RS, Colizza K, Wang W, O'Connell TN, Coelho RV Jr, Kelley RM, Schildknegt K. Metabolism, pharmacokinetics, and excretion of the 5-hydroxytryptamine1b receptor antagonist elzasonan in humans. Drug Metab Dispos. 2010 Nov;38(11):1984-99. doi: 10.1124/dmd.110.034595. Epub 2010 Jul 28. PubMed PMID: 20668248.