WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525061
CAS#: 442198-67-6 (free)
Description: FK-330 is a novel inducible nitric oxide synthase inhibitor. It prevents ischemia and reperfusion injury in rat liver transplantation.
Hodoodo Cat#: H525061
Name: FK-330
CAS#: 442198-67-6 (free)
Chemical Formula: C29H28ClF3N6O4
Exact Mass: 616.18
Molecular Weight: 617.020
Elemental Analysis: C, 56.45; H, 4.57; Cl, 5.75; F, 9.24; N, 13.62; O, 10.37
Related CAS #: 442198-67-6 (free) 682813-92-9(dihydrate),
Synonym: FK-330; FK 330; FK330; FR-260330; FK-330; LS-192510.
IUPAC/Chemical Name: 2-Pyridinepropanamide, alpha-(((2E)-3-(4-chlorophenyl)-1-oxo-2-propen-1-yl)amino)-N-(2-oxo-2-(4-((6-(trifluoromethyl)-4-pyrimidinyl)oxy)-1-piperidinyl)ethyl)-, (alphaS)-
InChi Key: MVJHAYBYNRTWJF-CJHOVAGGSA-N
InChi Code: InChI=1S/C29H28ClF3N6O4/c30-20-7-4-19(5-8-20)6-9-25(40)38-23(15-21-3-1-2-12-34-21)28(42)35-17-27(41)39-13-10-22(11-14-39)43-26-16-24(29(31,32)33)36-18-37-26/h1-9,12,16,18,22-23H,10-11,13-15,17H2,(H,35,42)(H,38,40)/b9-6+/t23-/m0/s1
SMILES Code: O=C(NCC(N1CCC(OC2=NC=NC(C(F)(F)F)=C2)CC1)=O)[C@@H](NC(/C=C/C3=CC=C(Cl)C=C3)=O)CC4=NC=CC=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 617.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Tsuchihashi S, Kaldas F, Chida N, Sudo Y, Tamura K, Zhai Y, Qiao B, Busuttil RW, Kupiec-Weglinski JW. FK330, a novel inducible nitric oxide synthase inhibitor, prevents ischemia and reperfusion injury in rat liver transplantation. Am J Transplant. 2006 Sep;6(9):2013-22. Epub 2006 Jun 22. PubMed PMID: 16796718.
