WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525071
CAS#: 7456-24-8
Description: Fonazine, also known as Dimetotiazine, is a phenothiazine drug used for the treatment of migraine. It is a serotonin antagonist and histamine antagonist.
Hodoodo Cat#: H525071
Name: Fonazine
CAS#: 7456-24-8
Chemical Formula: C19H25N3O2S2
Exact Mass: 391.14
Molecular Weight: 391.550
Elemental Analysis: C, 58.28; H, 6.44; N, 10.73; O, 8.17; S, 16.38
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Fonazine; Dimetotiazine; Dimethothiazine; Dimetiotazine; Banistyl; Dimethodin; fonazine mesylate; fonazine monomesylate ;Migristene; Promaquid.
IUPAC/Chemical Name: 10-(2-(Dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide
InChi Key: VWNWVCJGUMZDIU-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H25N3O2S2/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5/h6-12,14H,13H2,1-5H3
SMILES Code: CC(CN1c2ccccc2Sc3c1cc(cc3)S(=O)(=O)N(C)C)N(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, not in water
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 391.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Takagi H, Takashima M, Liou SY. [Effect of KB-2796, a novel calcium channel blocker, on spreading depression in rat hippocampal slices]. Nihon Yakurigaku Zasshi. 1998 May;111(5):309-16. Japanese. PubMed PMID: 9666486.
2: Shimazawa M, Hara H, Watano T, Sukamoto T. Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br J Pharmacol. 1995 Aug;115(8):1359-68. PubMed PMID: 8564192; PubMed Central PMCID: PMC1908864.
3: Castro-Gago M, Couceiro JA, Novo-Rodríguez I, Méndez MJ, Fernández Seara MJ, Eirís J. [Migraine in childhood and adolescence: a retrospective review of hospital cases]. Rev Neurol. 1995 Jul-Aug;23(122):769-72. Spanish. PubMed PMID: 7497237.
