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Featured Products
PF-04827736
CAT#: H471102
CAS#: Unknown
PF-04827736 is a non-brain penetrant potent and selective inhibitor of PDE1
PF-04856264
CAT#: H522582
CAS#: 1235397-05-3
PF-04856264 is a potent, selective inhibitor of the human Nav1.7 voltage gated sodium channel (IC50 = 28 nM). The voltage-gated sodium channel NaV1.7 …
PF-04859989 HCl
CAT#: H532461
CAS#: 177943-33-8 (PF-04859989 HCl)
PF-04859989 HCl is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain…
PF-04880594
CAT#: H406212
CAS#: 1111636-35-1
PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-048805…
PF-04885614
CAT#: H471092
CAS#: 1480833-70-2
PF-04885614 is a potent and selective Nav1.8 channel blocker.
PF-04929113 free base
CAT#: H206217
CAS#: 908115-27-5 (free base)
PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. …
PF-04929113 mesylate
CAT#: H206835
CAS#: 1173111-67-5 (mesylate)
PF-04929113, also known as SNX-5422; is a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. …
PF-04937319
CAT#: H522488
CAS#: 1245603-92-2
PF-04937319 is a glucokinase activator which is under development for the treatment of type 2 diametes mellitus. Glucose-phosphorylating enzyme, gluco…
PF-04979064
CAT#: H525950
CAS#: 1220699-06-8
PF-04979064 is a potent and selective PI3K/mTOR inhibitor. PF-04979064 regulates tumor growth in gastric cancer and enhances drug sensitivity of gastr…
PF-04981517
CAT#: H551013
CAS#: 1390637-82-7
PF-04981517, also known as CYP3cide, is a potent and selective time dependent inactivator of Cytochrome P450 3A4 (CYP3A4). CYP3cide is a very useful …
PF-04991532
CAT#: H522525
CAS#: 1215197-37-7
PF-04991532 is a potent and selective hepatoselective glucokinase activator. PF-04991532 ameliorates hyperglycemia without causing hepatic steatosis…
PF-04995274
CAT#: H525952
CAS#: 1331782-27-4
PF-04995274 is a 5-HT4 receptor partial agonist. It is thought to act centrally as a pro-cognitive agent that is being developed for the treatment of …
PF-05085727
CAT#: H530657
CAS#: 1415637-72-7
PF-05085727 is a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor. PF-05085727 demonstrated in vivo activity as evidenced by bioc…
PF-05089771
CAT#: H530305
CAS#: 1235403-62-9 (free base)
PF-05089771 is a Selective Nav1.7 Inhibitor (IC50 = 11 nM) that interacts with the voltage-sensor domain (VSD) of domain IV. PF-05089771 exhibits a s…
PF-05089771 Tosylate
CAT#: H526590
CAS#: 1430806-04-4 (tosylate)
PF-05089771 Tosylate is a novel potent and selective human Nav1.7 blocker.
PF-05105679
CAT#: H522489
CAS#: 1398583-31-7
PF-05105679 is a selective TRPM8 Antagonist (IC50 = 103 nM) with clinical efficacy in cold-related pain. The transient receptor potential (TRP) famil…
PF-05180999
CAT#: H520521
CAS#: 1394033-54-5
PF-05180999 is a potent and selective PDE2a inhibitor (PDE2a IC50 = 0.001 μM, 2000-fold selective over PDE10) with a reasonable free brain/plasma rati…
PF-05212377 succinate
CAT#: H471100
CAS#: Unknown
PF05212377 succinate, also known as SAM-760, is a 5-HT6R antagonist which were evaluated in clinical trials as potential AD therapy.
PF-05236216 hydrochloride
CAT#: H531367
CAS#: 1383376-93-9
PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhyt…
PF-05241328
CAT#: H530927
CAS#: 1387633-03-5
PF-05241328 is a potent and selective inhibitor of Human Nav1.7 Voltage-Dependent Sodium Channel. PF-05089771 provided the best opportunity to explore…
PF-06250112
CAT#: H341196
CAS#: 1609465-89-5
PF-06250112 is a potent inhibitor of Bruton′s tyrosine kinase.
PF-06260414
CAT#: H522576
CAS#: 1612755-71-1
PF-06260414 is a selective androgen receptor modulator, or SARM, which is developed to treat muscle weakening. Testosterone’s anabolic properties help…
PF-06260933
CAT#: H527680
CAS#: 1811510-56-1 (free base)
PF-06260933 is a potent and highly selective inhibitor of MAP4K4.
PF-06260933 HCl
CAT#: H523116
CAS#: 1883548-86-4 (2HCl)
PF-06260933 dihydrochloride is a MAP4K4 (HGK) inhibitor (IC50 = 140 nM). It also inhibits MINK and TNIK (IC50 values are 8 and 13 nM, respectively). P…
PF-06263276
CAT#: H530381
CAS#: 1421502-62-6
PF-06263276 is a potent and selective pan-JAK inhibitor which is suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases …
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