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Featured Products
PF-06281355
CAT#: H531253
CAS#: 1435467-38-1
PF-06281355, also known as PF-1355, is an orally available, selective and potent mechanism based inhibitor of the myeloperoxidase (MPO) that reduces p…
PF-06282999
CAT#: H522473
CAS#: 1435467-37-0
PF-06282999 is a potent and selective myeloperoxidase Inhibitor which is potential useful for the Treatment of Cardiovascular Diseases. PF-06282999 di…
PF-06284674
CAT#: H531366
CAS#: 1434288-24-0
PF-06284674 is a cell permeable, potent and selective M2 isoform of pyruvate kinase (PKM2) activator.
PF-06291874
CAT#: H530531
CAS#: 1393124-08-7
PF-06291874 is a glucagon receptor antagonist that is potentially useful for patients with type 2 diabetes mellitus. PF-06291874 was well tolerated, h…
PF-06297470
CAT#: H555416
CAS#: 1539296-45-1
PF-06297470 is a potent negative allosteric modulator of the Metabotropic Glutamate Receptor 5 (mGluR5). PF-06297470 binds to mGluR5 with a Ki of 0.9 …
PF-06305591
CAT#: H465708
CAS#: 1449473-97-5
PF-06305591 is a potent and highly selective sodium channel Nav1.8 inhibitor.
PF-06409577
CAT#: H526836
CAS#: 1467057-23-3
PF-06409577 is a potent and selective activator of 5′ adenosine monophosphate-activated protein kinase (AMPK) for the Potential Treatment of diabetic …
PF-06412154 HCl
CAT#: H471094
CAS#: 1421349-19-0
PF-06412154 HCl is a glucagon receptor antagonist.
PF-06422913
CAT#: H531362
CAS#: 1539296-46-2
PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
PF-06424439
CAT#: H522401
CAS#: 1469284-78-3 (free base)
PF-06424439 is a potent and selective Diacylglycerol Acyltransferase 2 ( DGAT2) inhibitor with DGAT2 IC50 ± SEM (nM) (human/rat/dog) 14 ± 1/38 ± 4/16 …
PF-06424439 Mesylate
CAT#: H563632
CAS#: 1469284-79-4 (mesylate)
PF-06424439 Mesylate is a potent and selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
PF-06427878
CAT#: H471107
CAS#: 1809064-23-0
PF-06427878 is an orally active, potent and selective diacylglycerol acyltransferase 2 inhibitor.
PF-06439015 mesylate
CAT#: H341197
CAS#: 1565822-20-9 (mesylate)
PF-06439015 is a potent and selective inhibitor that overcomes clinical ALK (receptor tyrosine kinase anaplastic lymphoma kinase) mutations resistant …
PF-06442609
CAT#: H522464
CAS#: 1402002-76-9
PF-06442609 is a potent, metabolic stable γ-secretase modulators (GSMs) for Alzheimer's disease (AD). PF-06442609 displayed a favorable rodent pharma…
PF-06446846 HCl
CAT#: H531361
CAS#: 1632250-50-0 (HCl)
PF-06446846 is a selective orally active PCSK9 inhibitor that appears to act by causing the ribosome to stall when synthesizing PCSK9. PCSK9 binds to …
PF-06454589
CAT#: H532463
CAS#: 1527473-30-8
PF-06454589 is a potent and selective LRRK2 inhibitor.
PF-06459988
CAT#: H206549
CAS#: 1428774-45-1
PF-06459988 is an orally available, small molecule, third-generation, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant (EGFRm)…
PF-06462894
CAT#: H530922
CAS#: 1622291-66-0
PF-06462894 is a morpholinopyrimidone mGlu5 (mGlu5 Ki = 6 nM). PF-06462894 possessed favorable properties and a predicted low clinical dose (2 mg twic…
PF-06463922 acetate
CAT#: H531357
CAS#: 1924207-18-0
PF-06463922 acetate is a potent, selective brain-penetrable inhibitor of both anaplastic lymphoma kinase (ALK) and c-ros Oncogene 1 (ROS1) with strong…
PF-06465469
CAT#: H555203
CAS#: 1407966-77-1
PF-06465469 is a potent, covalent inhibitor of the nonreceptor tyrosine kinase Itk (IL-2 inducible T-cell kinase), which is expressed primarily in imm…
PF-06648671
CAT#: H562016
CAS#: 1587727-31-8
PF-06648671 is a γ-secretase modulator or Amyloid precursor protein secretase modulator for the treatment of neurodegenerative and/or neurological dis…
PF-06650833
CAT#: H530304
CAS#: 1817626-54-2
PF-06650833, also known as Zimlovisertib, is an inhibitor of Interleukin-1 receptor associated kinase 4 (IRAK4). RAK4 is located proximal to TLR/IL-1…
PF-06651481-00
CAT#: H561539
CAS#: 1391063-17-4
PF-06651481-00, also known as Bosutinib Isomer I, is an analog of bosutinib, and a Bcr-Abl kinase inhibitor.
PF-06651600 free base
CAT#: H555328
CAS#: 1792180-81-4 (free base)
Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrat…
PF-06658607
CAT#: H471095
CAS#: 1621002-24-1
PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor.
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