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Featured Products
PF-06928215
CAT#: H463890
CAS#: 2378173-15-8
PF-06928215 is an inhibitor of cyclic GMP-AMP synthase.
PF-06952229
CAT#: H462426
CAS#: 1801333-55-0
PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal tr…
PF-07104091
CAT#: H207162
CAS#: 2460249-19-6
Tagtociclib, also known as PF-07104091, is an orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activit…
PF-07220060
CAT#: H207196
CAS#: 2380321-51-5
PF-07220060 is a novel potent oral CDK4-selective inhibitor. PF-07220060 is under clinical development by Pfizer and currently in Phase I for Metastat…
PF-07321332
CAT#: H555985
CAS#: 2628280-40-8
Nirmatrelvir, also known as PF-07321332 (brand name: Paxlovid), is an orally bioavailable 3C-like protease (3CLPRO) inhibitor and SARS-CoV-2 Mpro inhi…
PF-184
CAT#: H527693
CAS#: 1187460-81-6
PF-184 is a potent and selective IKK-2 inhibitor, demonstrating target-specific anti-inflammatory activities in cellular assays and following oral and…
PF-249
CAT#: H562066
CAS#: 1467059-70-6
PF-249, also known as PF-06685249, is a beta1-selective AMPK agonist. PF-06685249 is a potent AMPK activator. PF-06685249 exhibited robust activation…
PF-3187207
CAT#: H561500
CAS#: 860005-21-6
Latanoprostene, also known as PF-3187207, is a a nitric oxide (NO)-donating latanoprost with prostaglandin activity. It loweres intraocular pressure (…
PF-3274167
CAT#: H522639
CAS#: 900510-03-4
PF-3274167, also known as PF-03274167 or PF-327,4167, is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist. Oxytocin recep…
PF-3644022
CAT#: H532465
CAS#: 1276121-88-0
PF-3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 n…
PF-3774076
CAT#: H531336
CAS#: 1171824-96-6
PF-3774076 is a CNS penetrant, potent, selective, partial agonist at the human α1A adrenoceptor. PF-3774076 is selective over α1B and α1D adrenoceptor…
PF-3845
CAT#: H503210
CAS#: 1196109-52-0
PF-3845 is a fatty acid amide hydrolase (FAAH) inhibitor, and acts in the nervous system to reverse LPS-induced tactile allodynia in mice. PF-3845 pr…
PF-4191834
CAT#: H522524
CAS#: 1029317-21-2
PF-4191834 is a novel, potent and selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. PF-4191834 exhibits good potency …
PF-429242
CAT#: H525966
CAS#: 947303-87-9
PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site …
PF-431396
CAT#: H407200
CAS#: 717906-29-1
PF-431396 is a potent and selective focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respe…
PF-4455242 HCl
CAT#: H525967
CAS#: 1322001-35-3 (HCl)
PF-4455242 is a selective, short-acting antagonist of the κ-opioid receptor. It was pursued in a phase I clinical trial for the treatment of bipolar d…
PF-4618433
CAT#: H563543
CAS#: 1166393-85-6
PF-4618433 is an inhibitor of proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK).
PF-4693627
CAT#: H530979
CAS#: 1312815-93-2
PF-4693627 is a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.
PF-4708671
CAT#: H406432
CAS#: 1255517-76-0
PF-4708671 is a novel cell-permeable inhibitor of S6K1. PF-4708671 specifically inhibits the S6K1 isoform with a Ki of 20 nM and IC50 of 160 nM. PF-47…
PF-477736
CAT#: H563171
CAS#: 952021-60-2 (free base)
PF-477736, also known as PF-00477736, is a potent CHK1 inhibitor with potential chemopotentiation activity. PF-477736 inhibits chk1, an ATP-dependent…
PF-4778574
CAT#: H525970
CAS#: 1219633-99-4
PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.
PF-4800567
CAT#: H532466
CAS#: 1188296-52-7 (free base)
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. PF4800567 significantly …
PF-4800567 hydrochloride
CAT#: H531335
CAS#: 1391052-28-0 (HCl)
PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ. PF4800567 significantly …
PF-4840154
CAT#: H532467
CAS#: 1332708-14-1
PF-4840154 is a non-electrophilic reference agonist of the TrpA1 channel. The TRPA1 channel is considered an attractive pain target based on the fact …
PF-4989216
CAT#: H406267
CAS#: 1276553-09-3
PF-4989216 is a novel potent and selective PI3K inhibitor. PF-4989216 inhibits the phosphorylation of PI3K downstream molecules and subsequently leads…
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