WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H556177
CAS#: 2813335-07-6 (rotation negative)
Description: (–)-IHCH7041 is a optical rotation negative isomer of IHCH7041. (–)-IHCH7041 is a DRD2 partial agonist. (–)-IHCH7041 showed EC50 = 1.38 nM in Gαi1–γ9 dissociation and 2.75 nM in β-arrestin2 recruitment. (–)-IHCH7041 exhibited a inhibition constant (Ki) of 22.44 nM binding affinity at DRD2. (–)-IHCH7041 has antidepressant properties and reverses cognitive impairment.
Hodoodo Cat#: H556177
Name: (–)-IHCH7041
CAS#: 2813335-07-6 (rotation negative)
Chemical Formula: C24H35N5O
Exact Mass: 409.28
Molecular Weight: 409.578
Elemental Analysis: C, 70.38; H, 8.61; N, 17.10; O, 3.91
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Related CAS #: 2813335-29-2 (rel-) 2813335-07-6 (rotation negative) 2813335-06-5 (rotation positive)
Synonym: (–)-IHCH7041; IHCH-7041; IHCH 7 041; IHCH7041;
IUPAC/Chemical Name: N′-[trans-4-[2-[(6aS)-4,6,6a,7,9,10-Hexahydro-8H-pyrazino[1,2-a]pyrrolo[4,3,2-de]quinolin-8-yl]ethyl]cyclohexyl]-N,N-dimethylurea
InChi Key: BRKGSTSSCHWCSJ-IHPCNDPISA-N
InChi Code: InChI=1S/C24H35N5O/c1-27(2)24(30)26-19-8-6-17(7-9-19)10-11-28-12-13-29-20(16-28)14-18-15-25-21-4-3-5-22(29)23(18)21/h3-5,15,17,19-20,25H,6-14,16H2,1-2H3,(H,26,30)/t17-,19-,20-/m0/s1
SMILES Code: O=C(N[C@H]1CC[C@H](CCN(CC2)C[C@@](C3)([H])N2C4=C5C3=CNC5=CC=C4)CC1)N(C)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 409.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Chen Z, Fan L, Wang H, Yu J, Lu D, Qi J, Nie F, Luo Z, Liu Z, Cheng J, Wang S. Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat Neurosci. 2022 Jan;25(1):39-49. doi: 10.1038/s41593-021-00971-w. Epub 2021 Dec 9. PMID: 34887590.
