WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130081
CAS#: N/A
Description: Z-Leu-Homophe-CHF2 is a SARS-CoV-2 Mpro inhibitor.
Hodoodo Cat#: H130081
Name: Z-Leu-Homophe-CHF2
CAS#: N/A
Chemical Formula: C25H32F2N2O5
Exact Mass: 478.23
Molecular Weight: 478.540
Elemental Analysis: C, 62.75; H, 6.74; F, 7.94; N, 5.85; O, 16.72
This product is not in stock, which may be available by custom synthesis.
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Synonym: Z-Leu-Homophe-CHF2; Z Leu Homophe CHF2
IUPAC/Chemical Name: Benzyl ((2S)-1-((1,1-difluoro-2-oxo-5-phenylpentan-3-yl)amino)-4-methyl-1-oxopentan-2-yl)carbamate monohydrate
InChi Key: SNXHDQOKRFLXJX-NPTNJNKCSA-N
InChi Code: InChI=1S/C25H30F2N2O4.H2O/c1-17(2)15-21(29-25(32)33-16-19-11-7-4-8-12-19)24(31)28-20(22(30)23(26)27)14-13-18-9-5-3-6-10-18;/h3-12,17,20-21,23H,13-16H2,1-2H3,(H,28,31)(H,29,32);1H2/t20?,21-;/m0./s1
SMILES Code: O=C(OCC1=CC=CC=C1)N[C@@H](CC(C)C)C(NC(CCC2=CC=CC=C2)C(C(F)F)=O)=O.[H]O[H]
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 478.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Citarella A, Gentile D, Rescifina A, Piperno A, Mognetti B, Gribaudo G, Sciortino MT, Holzer W, Pace V, Micale N. Pseudo-Dipeptide Bearing α,α-Difluoromethyl Ketone Moiety as Electrophilic Warhead with Activity against Coronaviruses. Int J Mol Sci. 2021 Jan 30;22(3):1398. doi: 10.3390/ijms22031398. PMID: 33573283; PMCID: PMC7866854.
