Besifloxacin

CAT#: H300142

CAS#: 141388-76-3

Description: Besifloxacin is a fourth-generation fluoroquinolone antibiotic. The marketed compound is besifloxacin hydrochloride. It was developed by SSP Co. Ltd., Japan, and designated SS734. SSP licensed U.S. and European rights to SS734 for ophthalmic use to InSite Vision Incorporated (OTCBB: INSV) in 2000. InSite Vision developed an eye drop formulation (ISV-403) and conducted preliminary clinical trials before selling the product and all rights to Bausch & Lomb in 2003.

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Synthetic Routes

Besifloxacin - Synthetic Route 1

Besifloxacin route01

Synthetic reference

Process for the preparation of besifloxacin and pharmaceutically acceptable salts thereof Rajadhyaksha, Mangesh Narayan; Nair, Ranjeet; Shrigadi, Nilesh Balkrishna; Panandikar, Aditi Assignee Indoco Remedies Limited, India 2014 Patent Information Sep 26, 2014 IN 2013MU00023 A

Besifloxacin - Synthetic Route 2

Besifloxacin route02

Synthetic reference

Process for preparation of besifloxacin Yan, Libo; Wang, Li; Nan, Qiuli; Cheng, Si Assignee Anhui Sainuo Pharmaceutical Chemical Engineering Co., Ltd., Peop. Rep. China; Farmasino Pharmaceuticals (Jiangsu) Co., Ltd. 2013 Patent Information Apr 17, 2013 CN 103044397 A

Besifloxacin - Synthetic Route 3

Besifloxacin route03

Synthetic reference

Harms, Arthur E. Process for preparation of azepanylfluoroquinolonecarboxylates from chloroquinolines and azepan derivatives and their use as antibacterials. Assignee Bausch & Lomb Incorporated, USA. (2008).