Cabazitaxel

CAT#: H200585

CAS#: 183133-96-2

Description: Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

img

Synthetic Routes

Cabazitaxel - Synthetic Route 1

Cabazitaxel route01

Synthetic reference

Jing, Yun-rong; Zhou, Wei; Li, Wan-liang; Zhao, Lin-xiang; Wang, Yong-feng; Bioorganic & Medicinal Chemistry, Volume 22, Issue 1, Pages 194-203, Journal, 2014

Cabazitaxel - Synthetic Route 2

Cabazitaxel route02

Synthetic reference

Zhang, Guoning; Fang, Weishuo Journal of Chinese Pharmaceutical Sciences Volume 21 Issue 5 Pages 472-476 Journal 2012

Cabazitaxel - Synthetic Route 3

Cabazitaxel route03

Synthetic reference

Li, Caihong; Qiu, Yatao; Li, Xing; Liu, Nianjin; Yao, Zhiyi Bioorganic & Medicinal Chemistry Letters Volume 24 Issue 3 Pages 855-859 Journal; 2014

Cabazitaxel - Synthetic Route 4

Cabazitaxel route04

Synthetic reference

Method for preparation of Cabazitaxel Sun, Xiaoqiang; Chen, Xin; Yang, Haitao; Miao, Chunbao Assignee Changzhou University, Peop. Rep. China 2011 Patent Information Dec 21, 2011 CN 102285947 A

Cabazitaxel - Synthetic Route 5

Cabazitaxel route05

Synthetic reference

Simo, Ondrej; Vraspir, Pavel; Holas, Tomas; Jegorov, Alexandr; Gabriel, Roman. Processes for preparation of solid state forms of cabazitaxel. Assignee Plus Chemicals SA, Switz.; Teva Pharmaceuticals USA, Inc. WO 2012142117. (2012).

Cabazitaxel - Synthetic Route 6

Cabazitaxel route06

Synthetic reference

Liu, Ping; Yuan, Jiandong. Method for synthesis of Cabazitaxel from 10-deacetylbaccatin III. Assignee Xintai Pharmaceutical (Suzhou) Co., Ltd., Peop. Rep. China. CN 102659721. (2012).

Cabazitaxel - Synthetic Route 7

Cabazitaxel route07

Synthetic reference

Sethi, Madhuresh Kumar; Mahajan, Sanjay; Mara, Bhairaiah; Veera, Upendranath. Process for the preparation of cabazitaxel and its solvates. Assignee Mylan Laboratories Ltd., India. IN 2013CH05688. (2016).

Cabazitaxel - Synthetic Route 8

Cabazitaxel route08

Synthetic reference

Hsiao, Tsungyu; Henschke, Julian Paul; Tseng, Hsinchang. Process for the preparation of cabazitaxel, and 1,3-dithiolane or 1,3-dithiane intermediates thereof. Assignee ScinoPharm Taiwan Ltd., Taiwan. US 20130116444. (2013).