Carglumic acid

CAT#: H317372

CAS#: 1188-38-1

Description: Carglumic acid is an orphan drug, marketed by Orphan Europe under the trade name Carbaglu. Carglumic acid is used for the treatment of hyperammonaemia in patients with N-acetylglutamate synthase deficiency. The initial daily dose ranges from 100 to 250 mg/kg, adjusted thereafter to maintain normal plasma levels of ammonia.

img

Synthetic Routes

Carglumic acid - Synthetic Route 1

Carglumic acid route01

Synthetic reference

Verardo, Giancarlo; Geatti, Paola; Strazzolini, Paolo Synthetic Communications Volume 37 Issue 11 Pages 1833-1844 Journal 2007

Carglumic acid - Synthetic Route 2

Carglumic acid route02

Synthetic reference

Liu, Yaqian; Yang, Hao; Xiang, Yang Jingxi Huagong Zhongjianti Volume 41 Issue 1 Pages 29-31, 48 Journal 2011

Carglumic acid - Synthetic Route 3

Carglumic acid route03

Synthetic reference

Qiao, Shiyan; Yue, Longyao; Huang, Xuebin; Wang, Chunping. Method for preparing N-carbamylglutamic acid. Assignee Beijing Longkefangzhou Biology Engineering Center, Peop. Rep. China. CN 101440042. (2009).

Carglumic acid - Synthetic Route 4

Carglumic acid route04

Synthetic reference

Shu, Xugang; Gao, Junyong; Xu, Xiang; Yin, Yulong. Zinc n-aminoformyl-l-glutamate complexes and the preparation method thereof. Assignee Guangzhou Jiuyi Biotechnology Co., Ltd., Peop. Rep. China. CN 102603778. (2012).

Carglumic acid - Synthetic Route 5

Carglumic acid route05

Synthetic reference

Cao, Fei; Li, Wenhui; Wu, Hongli; Tang, Zhiqun; Hong, Weiming; Lu, Hui. Method for crystallizing N-carbamyl-glutamic acid by acidifying with mixed acid. Assignee Nanjing Tech University, Peop. Rep. China. CN 105601542. (2016).