Doripenem Monohydrate

CAT#: H329007

CAS#: 364622-82-2

Description: Doripenem Monohydrate, also known as S-4661 and Finibax, is a beta-lactam class drug used for bacterial infections with ultra-broad antibiotic spectrum. Doripenem Monohydrate is used commonly for the treatment of complicated intra-abdominal infections and complicated urinary tract infections.

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Synthetic Routes

Doripenem Monohydrate - Synthetic Route 1

Doripenem Monohydrate route01

Synthetic reference

Zhang, Aiyan; Zhu, Xueyan; Yuan, Zhedong Zhongguo Yiyao Gongye Zazhi Volume 37 Issue 6 Pages 361-363 Journal 2006

Doripenem Monohydrate - Synthetic Route 2

Doripenem Monohydrate route02

Synthetic reference

Preparation of pyrrolidinothiocarbapenem derivative and intermediate; Tang, Zhijun; Zhang, Qingwen; Shi, Huilin; Assignee Shanghai Institute of Pharmaceutical Industry, Peop. Rep. China; 2007; Patent Information; Aug 01, 2007; CN; 101007806; A

Doripenem Monohydrate - Synthetic Route 3

Doripenem Monohydrate route03

Synthetic reference

Nishino, Yutaka; Kobayashi, Makoto; Shinno, Taneyoshi; Izumi, Kenji; Yonezawa, Hiroshi; Masui, Yoshiyuki; Takahira, Masayuki; Organic Process Research & Development; Volume 7; Issue 6; Pages 846-850; Journal; 2003

Doripenem Monohydrate - Synthetic Route 4

Doripenem Monohydrate route04

Synthetic reference

Tewari, Neera; George, Vinod; Mane, Avinash Sheshrao; Meeran, Hashim Nizar Poovanathil Nagoor; Prasad, Mohan. A process for the preparation of carbapenem compounds. Assignee Ranbaxy Laboratories Ltd., India. WO 2007029084. (2007).

Doripenem Monohydrate - Synthetic Route 5

Doripenem Monohydrate route05

Synthetic reference

Tseng, Wei-Hong; Chang, Wen-Hsin; Chang, Chia-Mao; Yeh, Chia-Wei; Kuo, Yuan-Liang. Improved process for the preparation of carbapenem using carbapenem intermediates and recovery of carbapenem. Assignee Savior Lifetec Corp., Taiwan. EP 2388261. (2011).

Doripenem Monohydrate - Synthetic Route 6

Doripenem Monohydrate route06

Synthetic reference

Yu, Yuan; Zhou, Wuchun; Xu, Dayong; Huang, Yu; Liu, Zhongrong; Li, Bogang; Zhou, Hongying; Zhang, Mei; Duan, Chengwang. Novel crystal of Doripenem, its preparation method and application. Assignee Chengdu Diao Jiuhong Pharmaceutical Factory, Peop. Rep. China. CN 101100469. (2008).

Doripenem Monohydrate - Synthetic Route 7

Doripenem Monohydrate route07

Synthetic reference

Jiang, Yu-qin; Ma, Jin-shuo; Xu, Gui-qing; Wu, Dou-can; Wang, Jun-qiang; Li, Wei. New synthetic route of doripenem. Zhongguo Xinyao Zazhi. Volume 22. Issue 1. Pages 100-102, 106. 2013.

Doripenem Monohydrate - Synthetic Route 8

Doripenem Monohydrate route08

Synthetic reference

Tang, Zhijun; Zhang, Qingwen; Shi, Huilin. Preparation of pyrrolidinothiocarbapenem derivative and intermediate. Assignee Shanghai Institute of Pharmaceutical Industry, Peop. Rep. China. CN 101007806. (2007).

Doripenem Monohydrate - Synthetic Route 9

Doripenem Monohydrate route09

Synthetic reference

Xu, Dayong; Tang, Yun; Zhou, Wuchun; Yu, Yuan; Liu, Zhongrong; Li, Bogang. Preparation of pyrrolidine derivatives as Doripenem intermediates.Assignee Chengdu Diao Jiuhong Pharmaceutical Factory, Peop. Rep. China. CN 1896057. (2007).

Doripenem Monohydrate - Synthetic Route 10

Doripenem Monohydrate route010

Synthetic reference

Lin, Kaichao; Li, Xingmin; Tao, Youni. Novel process for preparation of Doripenem.Assignee Hunan Ouya Biological Co., Ltd., Peop. Rep. China. CN 102174047. (2011).