Description:
Dronedarone is an antiarrhythmic, acting as a multichannel blocker. Dronedarone inhibits multiple outward potassium currents and reduces inward rapid Na current and L-type Ca channels.
Process for the preparation of dronedarone; Gutman, Arie L.; Nisnevich, Gennady; Yudovitch, Lev; Assignee ISP Investments Inc., USA 2003; Patent Information; May 15, 2003; WO 2003040120 A1
Dronedarone - Synthetic Route 2
Synthetic reference
Process for preparation of Dronedarone and synthetic intermediates thereof; Marom, Ehud; Mizhiritskii, Michael; Rubnov, Shai; Assignee Mapi Pharma Holdings (Cyprus) Limited, Cyprus 2011; Patent Information; Aug 18, 2011; WO 2011099010 A1
Dronedarone - Synthetic Route 3
Synthetic reference
Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives; Richter, Frank; Schreiner, Erwin; Pirc, Samo; Copar; Anton Assignee Lek Pharmaceuticals d.d., Slovenia 2012; Patent Information; May 18, 2012; WO 2012062918 A1
Dronedarone - Synthetic Route 4
Synthetic reference
Rajan, Srinivasan Thirumalai; Eswaraiah, Sajja; Satyanarayana, Komati. Process for the preparation of dronedarone an known antiarrhythmic agent. Assignee MSN Laboratories Limited, India. IN 2012CH03310. (2016).
Dronedarone - Synthetic Route 5
Synthetic reference
Bollikonda, Satyanarayana; Mohanarangam, Saravanan; Chaganti, Sridhar; Jinna, Rajender Reddy; Madaraboina, Mahender. Process for the preparation of dronedarone and pharmaceutically acceptable salts thereof. Assignee Dr. Reddy's Laboratories Limited, India; Dr. Reddy's Laboratories Inc. IN 2010CH01080. (2012).
Dronedarone - Synthetic Route 6
Synthetic reference
Zhou, Xinji; Mao, Jincheng; Zhu, Jianjun; Li, Xunxun. A process for preparing dronedarone. Assignee Jiangsu Jiujiujiu Technology Co., Ltd., Peop. Rep. China. CN 103450124. (2013).
Dronedarone - Synthetic Route 7
Synthetic reference
Li, Feng; Jin, Chunhua; Zou, Jianwei; Wu, Jun. A facile and efficient synthesis of dronedarone hydrochloride. Bulletin of the Korean Chemical Society. Volume 35. Issue 7. Pages 1970-1972. 2014.
Dronedarone - Synthetic Route 8
Synthetic reference
Biard, Michel. 2-Butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride and preparation thereof. Assignee Sanofi-Synthelabo, Fr.. WO 2002048078. (2002).
Dronedarone - Synthetic Route 9
Synthetic reference
Mali, Anil C.; Ippar, Sharad S.; Bodke, Mahendra B.; Patil, Nilesh S.; Mathad, Vijayavitthal T. An Improved and Efficient Process for the Production of Dronedarone Hydrochloride, an Antiarrhythmia Drug. Organic Process Research & Development. Volume 17. Issue 5. Pages 863-868. 2013.
Dronedarone - Synthetic Route 10
Synthetic reference
Mahender, M.; Saravanan, M.; Sridhar, Ch.; Chandrashekar, E. R. R.; Kumar, L. Jaydeep; Jayashree, A.; Bandichhor, Rakeshwar. Identification and Characterization of Potential Impurities of Dronedarone Hydrochloride. Organic Process Research & Development. Volume 18. Issue 1. Pages 157-162. 2014.
