Gadoxetate disodium

CAT#: H564088

CAS#: 135326-22-6

Description: Gadoxetate Disodium is a liver-specific magnetic resonance imaging (MRI) contrast agent. Gadoxetate Disodium is preferentially taken up by normal functioning hepatocytes, so normal hepatic tissue is enhanced with MRI while tumor tissue is unenhanced.

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Synthetic Routes

Gadoxetate disodium - Synthetic Route 1

Gadoxetate disodium route01

Synthetic reference

Novel process for the preparation of gadolinium complex of (4s)-4-(4-ethoxybenzyl)-3,6,9-tris(carboxylatomethyl)-3,6,9- triazaundecanedioic acid disodium (gadoxetate disodium); Pullagurla, Manik Reddy; Pitta, Bhaskar Reddy; Namani, Suresh Babu; Rangisetty, Jagadeesh Babu; Assignee Biophore India Pharmaceuticals Pvt. Ltd., India; 2017; Patent Information; Dec 07, 2017; WO 2017208258 A1

Gadoxetate disodium - Synthetic Route 2

Gadoxetate disodium route02

Synthetic reference

Process for preparation of gadoxetate disodium and intermediates thereof; Leng, Chuanxin; Wang, Yubing; Zhang, Minghui; Fan, Chuanwen; Lin, Dong; Liu, Peiyuan; Zhang, Yonghui; Assignee Qilu Pharmaceutical Co., Ltd., Peop. Rep. China; 2013; Patent Information; Dec 04, 2013; CN 103420862 A