Hexaminolevulinate HCl

CAT#: H100423

CAS#: 140898-91-5


Description: Hexaminolevulinate hydrochloride, also known as hexyl 5-aminolevulinate HCl, is the hexyl ester of 5-aminolevulinic acid (ALA) with photodynamic properties. As a precursor of photoactive porphorins, hexyl 5-aminolevulinate induces the endogenous production of the photosensitizer protoporphyrin IX (PPIX) which accumulates selectively in tumor tissue. When exposed to specific wavelengths of light, PPIX is activated and, depending on the wavelength and/or intensity of light, either fluoresces, thereby allowing tumor imaging, or induces tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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Synthetic Routes

Hexaminolevulinate HCl - Synthetic Route 1

Hexaminolevulinate HCl route01

Synthetic reference

Dabrowski, Zbigniew; Kwasny, Miroslaw; Kaminski, Jaroslaw; Beldowicz, Maria; Lewicka, Lidia; Obukowicz, Bozena; Kaliszewski, Miron; Pirozynska, Ewa; Acta Poloniae Pharmaceutica; Volume 60; Issue 3; Pages 219-224; Journal; 2003

Hexaminolevulinate HCl - Synthetic Route 2

Hexaminolevulinate HCl route02

Synthetic reference

Seo, Jeong Hun; Shin, Dong Gyu; Cho, Sang Min; Won, Ye Rim; Kim, Jin Gyeong; Kim, Chang Seok. Method for the preparation of methyl 5-bromolevulinate and method for the preparation of hexyl 5-aminolevulinate hydrochloride using methyl 5-bromolevulinate. Assignee General Bio Co., Ltd., S. Korea. KR 2019004119. (2019).

Hexaminolevulinate HCl - Synthetic Route 3

Hexaminolevulinate HCl route03

Synthetic reference

He, Yong; Zhang, Junjie. Process for preparation of aminolevulinic acid hydrochloride. Assignee Shanghai Knowa Pharmaceutical Co., Ltd., Peop. Rep. China. CN 102649769. (2012).