Atazanavir

CAT#: H317254

CAS#: 198904-31-3 (free base)

Description: Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. It is sold under the trade name Reyataz. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus. Atazanavir is distinguished from other PIs in that it can be given once-daily and has lesser effects on the patient's lipid profile. Like other protease inhibitors, it is used only in combination with other HIV medications.

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Synthetic Routes

Atazanavir - Synthetic Route 1

Atazanavir route01

Synthetic reference

Fan, Xing; Song, Yan-Li; Long, Ya-Qiu. An efficient and practical synthesis of the HIV protease inhibitor Atazanavir via a highly diastereoselective reduction approach. Organic Process Research & Development. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. Volume 12. Issue 1. Pages 69-75. 2008.

Atazanavir - Synthetic Route 2

Atazanavir route02

Synthetic reference

Zhang, Huiping; Bonacorsi, Samuel J., Jr.; Chen, Bang-Chi; Leith, Leslie W.; Rinehart, J. Kent; Balasubramanian, Balu; Barrish, Joel C. A facile and efficient synthesis of d3-labelled Reyataz. Journal of Labelled Compounds & Radiopharmaceuticals. Discovery Chemistry, Pharmaceutical Research Institute, Bristol Myers Squibb Co. Volume 48. Issue 14. Pages 1041-1047. 2005.

Atazanavir - Synthetic Route 3

Atazanavir route03

Synthetic reference

Li, Jinliang. Process for preparation of Atazanavir. Assignee Shanghai Desano Pharmaceuticals Holding Co., Ltd., Peop. Rep. China; Shanghai Desano Pharmaceutical Co., Ltd.2012.

Atazanavir - Synthetic Route 4

Atazanavir route04

Synthetic reference

Fassler, Alexander; Bold, Guido; Capraro, Hans-Georg; Lang, Marc; Khanna, Satish Chandra. Preparation of antivirally active heterocyclic azahexane derivatives. Assignee Novartis A.-G., Switz. 1997.

Atazanavir - Synthetic Route 5

Atazanavir route05

Synthetic reference

Chen, Weiping. Process for synthesizing atazanavir. Assignee Oxyrane (Uk) Limited.2009.

Atazanavir - Synthetic Route 6

Atazanavir route06

Synthetic reference

Moro, Ravi Vithal; Herlekar, Pravin Shivdas. An improved process for the preparation of atazanavir. 2016.

Atazanavir - Synthetic Route 7

Atazanavir route07

Synthetic reference

Pizzocaro, Roberta; Galimi, Stefania; Rossi, Alessia. Process for the preparation of atazanavir. Assignee Solmag S.p.A. 2008.

Atazanavir - Synthetic Route 8

Atazanavir route08

Synthetic reference

Singh, Rakesh Kumar; Gottumukkala, Nagaraju; Khanna, Mahavir Singh; Thaper, Rajesh Kumar; Prasad, Mohan; Arora, Sudershan Kumar. Process for preparation of atazanavir or its bisulfate salt. Assignee Ranbaxy Laboratories Limited. 2013.