Dasabuvir

CAT#: H510275

CAS#: 1132935-63-7

Description: Dasabuvir, also known as ABT-333, is a non-nucleoside polymerase inhibitor currently under clinical trials for the treatment of Hepatitis C. In the United States, it is approved by the Food and Drug Administration for use in combination with ombitasvir, paritaprevir, and ritonavir in the product Viekira Pak. Dasabuvir acts as a NS5B (an RNA-directed RNA polymerase) inhibitor.

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Synthetic Routes

Dasabuvir - Synthetic Route 1

Dasabuvir route01

Synthetic reference

Barnes, David M.; Shekhar, Shashank; Dunn, Travis B.; Barkalow, Jufang H.; Chan, Vincent S.; Franczyk, Thaddeus S.; Haight, Anthony R.; Hengeveld, John E.; Kolaczkowski, Lawrence; Kotecki, Brian J.; Liang, Guangxin; Marek, James C.; McLaughlin, Maureen A.; Montavon, Donna K.; Napier, James J. Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor. Journal of Organic Chemistry. Volume 84. Issue 8. Pages 4873-4892. Journal; Online Computer File. (2019).

Dasabuvir - Synthetic Route 2

Dasabuvir route02

Synthetic reference

Shekhar, Shashank; Franczyk, Thaddeus S.; Barnes, David M.; Dunn, Travis B.; Haight, Anthony R.; Chan, Vincent S. Process for preparing antiviral pyrimidinylphenylnaphthalenyl sulfonamide compounds. Assignee AbbVie Inc., USA. WO 2014031791. (2014).

Dasabuvir - Synthetic Route 3

Dasabuvir route03

Synthetic reference

Shekhar, Shashank; Franczyk, Thaddeus S.; Barnes, David M.; Dunn, Travis B.; Haight, Anthony R.; Chan, Vincent S. Process for preparing antiviral pyrimidinylphenylnaphthalenyl sulfonamide compounds. Assignee AbbVie Inc., USA. US 20130224149. (2013).

Dasabuvir - Synthetic Route 4

Dasabuvir route04

Synthetic reference

Flentge, Charles A.; Hutchinson, Douglas K.; Betebenner, David A.; Degoey, David A.; Donner, Pamela L.; Kati, Warren M.; Krueger, Allan C.; Liu, Dachun; Liu, Yaya; Longenecker, Kenton L.; Maring, Clarence J.; Motter, Christopher E.; Pratt, John K.; Randolph, John T.; Rockway, Todd W.; Stewart, Kent D.; Wagner, Rolf; Barnes, David M.; Chen, Shuang; Franczyk, Thaddeus S., II; Gao, Yi; Haight, Anthony R.; Hengeveld, John E.; Kotecki, Brian J.; Lou, Xiaochun; Zhang, Geoff G. Z. Preparation of anti-infective pyrimidines for treating hepatitis C. Assignee Abbott Laboratories, USA. WO 2009039134. (2009).