Deferiprone

CAT#: H314217

CAS#: 30652-11-0

Description: Deferiprone is a drug that chelates iron and is used to treat thalassaemia major. In 1994 was first approved for use in treating thalassaemia major in 1994 and had been licensed for use in Europe and Asia for many years while awaiting approval in Canada and the United States. On October 14, 2011, it was approved for use in the US under the FDAÂ’s accelerated approval program.

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Synthetic Routes

Deferiprone - Synthetic Route 1

Deferiprone route01

Synthetic reference

Dobbin, Paul S.; Hider, Robert C.; Hall, Adrian D.; Taylor, Paul D.; Sarpong, Patience; Porter, John B.; Xiao, Gaoyi; van der Helm, Dick. Synthesis, physicochemical properties, and biological evaluation of N-substituted 2-alkyl-3-hydroxy-4(1H)-pyridinones: orally active iron chelators with clinical potential. Journal of Medicinal Chemistry. Volume 36. Issue 17. Pages 2448-58. Journal. (1993).

Deferiprone - Synthetic Route 2

Deferiprone route02

Synthetic reference

Fox, Raymond C.; Taylor, Paul D. Efficient syntheses of N-alkyl-3-hydroxy-2-methyl-4(1H)-pyridinones from carbohydrate precursors. Synthetic Communications. Volume 29. Issue 6. Pages 989-1001. Journal. (1999).