Dienogest

CAT#: H 315285

CAS#: 65928-58-7

Description: Dienogest is an orally active synthetic progesterone (or progestin). It is available for use as an oral contraceptive in combination with ethinylestradiol. It has antiandrogenic activity and as a result can improve androgenic symptoms. It is a non-ethinylated progestin which is structurally related to testosterone. Dienogest given in isolation is available for the treatment of endometriosis under the trade name Visanne.

img

Synthetic Routes

Dienogest - Synthetic Route 1

Dienogest route01

Synthetic reference

Liang, Yong; Chen, Bo; Wang, Shaojie. Synthesis of dienogest. Shenyang Yaoke Daxue Xuebao. Volume 28. Issue 10. Pages 788-790. Journal. (2011).

Dienogest - Synthetic Route 2

Dienogest route02

Synthetic reference

Chen, Liangkang; Zhang, Peiyi; Chen, Hailin; Chen, Jianxing. Synthesis of dienogest analogues and their biological activity on inhibition of luteal cells. Shengzhi Yu Biyun. Volume 32. Issue 1. Pages 5-9. Journal. (2012).

Dienogest - Synthetic Route 3

Dienogest route03

Synthetic reference

Doehler, Thomas; Walther, Dirk; Werner, Michael. Method for synthesis of dienogest from estrone-3-methylether. Assignee Heyl Chemisch-Pharmazeutische Fabrik Gmbh & Co. KG, Germany. US 20100298585. (2010).

Dienogest - Synthetic Route 4

Dienogest route04

Synthetic reference

Ding, Li; Li, Jinlu; Chen, Liying. Method for preparation of progestogens-Dienogestril. Assignee Tianjin Pharmaceuticals Research Institute Co., Ltd., Peop. Rep. China. CN 101353365. (2009).