Eliglustat

CAT#: H314252

CAS#: 491833-29-5

Description: Eliglustat, also known as GENZ-112638, (trade name Cerdelga) is a treatment for Gaucher's disease developed by Genzyme Corp that was approved by the FDA August 2014. Commonly used as the tartrate salt, Eliglustat is believed to work by inhibition of glucosylceramide synthase.

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Synthetic Routes

Eliglustat - Synthetic Route 1

Eliglustat route01

Synthetic reference

Sun, Guodong; Jian, Weilin; Luo, Zhonghua; Sun, Tengfei; Li, Chao; Zhang, Jiancun; Wang, Zhongqing. Development of an Efficient and Scalable Asymmetric Synthesis of Eliglustat via Ruthenium(II)-Catalyzed Asymmetric Transfer Hydrogenation. Organic Process Research & Development. Volume 23. Issue 6. Pages 1204-1212. Journal; Online Computer File. (2019).

Eliglustat - Synthetic Route 2

Eliglustat route02

Synthetic reference

Liu, Xiaoyu; Li, Xiaoyu; Yang, Hongguang; Shi, Xiang; Yang, Feilong; Jiao, Xiaozhen; Xie, Ping. Concise and efficient synthesis of eliglustat. Synthetic Communications. Volume 48. Issue 5. Pages 594-600. Journal; Online Computer File. (2018).

Eliglustat - Synthetic Route 3

Eliglustat route03

Synthetic reference

van den Berg, Richard J. B. H. N.; van Rijssel, Erwin R.; Ferraz, Maria Joao; Houben, Judith; Strijland, Anneke; Donker-Koopman, Wilma E.; Wennekes, Tom; Bonger, Kimberly M.; Ghisaidoobe, Amar B. T.; Hoogendoorn, Sascha; van der Marel, Gijsbert A.; Codee, Jeroen D. C.; Overkleeft, Herman S.; Aerts, Johannes M. F. G. Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors. ChemMedChem. Volume 10. Issue 12. Pages 2042-2062. Journal; Online Computer File. (2015).

Eliglustat - Synthetic Route 4

Eliglustat route04

Synthetic reference

Srinivasan, Thirumalai Rajan; Sajja, Eswaraiah; Ghojala, Venkat Reddy; Sagyam, Rajeshwar Reddy; Mallepally, Venkat Reddy; Koppera, Ravinder Reddy; Singavarapu, Adilakshmi; Rangineni, Srinivasulu. Stable N-[(1R,2R)-1-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-1-hydroxy-3-(pyrrolidin-1-yl)propan-2-yl]octanamide (2R,3R)-2,3-dihydroxysuccinate premix and process for preparation thereof. Assignee MSN Laboratories Private Limited, R&D Center, India. WO 2019082209. (2019).

Eliglustat - Synthetic Route 5

Eliglustat route05

Synthetic reference

Liu, Yu; Yu, Guangneng; Zheng, Zhiguo. Synthetic method of eliglustat and its intermediate. Assignee Zhejiang Ausun Pharmaceutical Co., Ltd., Peop. Rep. China. WO 2018171173. (2018).

Eliglustat - Synthetic Route 6

Eliglustat route06

Synthetic reference

Liu, Suyun; Feng, Piaochun. Eliglustat hemitartrate crystal form, preparation method and pharmaceutical composition. Assignee Beijing Qihui Medical Devices Co., Ltd., Peop. Rep. China. CN 107445938. (2017).

Eliglustat - Synthetic Route 7

Eliglustat route07

Synthetic reference

Gu, Haidong; Yuan, Weifeng; Sun, Yuejun; Luo, Huan. Process for the preparation of Eliglustat tartrate. Assignee Beijing Sunshine Nuohe Medicine Research Co., Ltd., Peop. Rep. China; Jiangsu Yongan Pharmaceutical Co., Ltd. CN 106349210. (2017).