Welcome to Hodoodo Chemicals

Balsalazide Disodium

CAT#: H317308

CAS#: 150399-21-6

Description: Balsalazide Disodium is the disodium salt form of balsalazide, an aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Mesalazine acts locally on the mucosa of the colon where it diminishes inflammation by blocking the production of arachidonic acid metabolites and other inflammatory agents. Balsalazide disodium is used to treat chronic inflammatory bowel disease.

Synthetic Routes

Balsalazide Disodium - Synthetic Route 1

Synthetic reference

Khan, Md. Umar; Baseer, M. A.; Kumar, S. Ranjith; Saravanakumar, M.; Prasannanjali, A. G.; Gupta, P. Badarinadh; Kaushik, Vipin K.; Handa, Vijay K.; Islam, Aminul. Synthesis and Characterization of Metabolites and Potential Impurities of Balsalazide Disodium, an Anti-Inflammatory Drug. Synthetic Communications. Chemical Research and Development Department, APL Research Centre. Aurobindo Pharma Ltd. Hyderabad, India 500 072. Volume 40. Issue 15. Pages 2241-2253. 2010

Balsalazide Disodium - Synthetic Route 2

Synthetic reference

Shi, Zhenhua; Ding, Jian; Ning, Qi; Zhang, Xiuping. Synthesis of balsalazide sodium. Zhongguo Yiyao Gongye Zazhi. Shanghai Institute of Pharmaceutical industry. Shanghai, Peop. Rep. China 200437. Volume 34. Issue 11. Pages 537-538. 2003

Balsalazide Disodium - Synthetic Route 3

Synthetic reference

Shan, Huijun; Fang, Gang; Wu, Song. Improvement on synthesis of balsalazide disodium. Zhongguo Yaowu Huaxue Zazhi. Institute of Materia Medica, Peking Union Medical College. Chinese Academy of Medical Sciences. Beijing, Peop. Rep. China 100050. Volume 11. Issue 2. Pages 110-111, 114. 2001

Balsalazide Disodium - Synthetic Route 4

Synthetic reference

Wang, Shaojie; Yao, Juanjuan; Yang, Fuan; Wu, Yuexia; Mu, Qingsu. Preparation of sodium balsalazide. Assignee Shanxi Ante Biological Pharmaceutical Co., Ltd., Peop. Rep. China. CN 101503377. 2009