Eslicarbazepine acetate

CAT#: H314220

CAS#: 236395-14-5

Description: Eslicarbazepine acetate is an antiepileptic drug. It is a prodrug which is activated to eslicarbazepine (S-licarbazepine), an active metabolite of oxcarbazepine.The European Medicines Agency (EMA) has recommended granting marketing authorization in 2009 for adjunctive therapy for partial-onset seizures, with or without secondary generalisation, in adults with epilepsy. (Source: http://en.wikipedia.org/wiki/Eslicarbazepine_acetate).

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Synthetic Routes

Eslicarbazepine acetate - Synthetic Route 1

Eslicarbazepine acetate route01

Synthetic reference

Ravinder, B.; Rajeshwar Reddy, S.; Sridhar, M.; Murali Mohan, M.; Srinivas, Katkam; Panasa Reddy, A.; Bandichhor, Rakeshwar. An efficient synthesis for eslicarbazepine acetate, oxcarbazepine, and carbamazepine. Tetrahedron Letters. Volume 54. Issue 22. Pages 2841-2844. Journal; Online Computer File. (2013).

Eslicarbazepine acetate - Synthetic Route 2

Eslicarbazepine acetate route02

Synthetic reference

Agarwal, Virendra Kumar. A process for the preparation of eslicarbazepine acetate. Assignee Amneal Pharmaceuticals Company GmbH, Switz. IN 2015MU03201. (2017).

Eslicarbazepine acetate - Synthetic Route 3

Eslicarbazepine acetate route03

Synthetic reference

Biswas, Sujay; Dubey, Shailendra Kumar; Bansal, Vikas; Vir, Dharam. Process for the preparation of (S)-(+)- or (R)-(-)-10-hydroxy-dihydrodibenz[b,f]azepines. Assignee Jubilant Life Sciences Limited, India. IN 2011DE00639. (2013).

Eslicarbazepine acetate - Synthetic Route 4

Eslicarbazepine acetate route04

Synthetic reference

Gharpure, Milind Moreshwar; Rane, Dnyandev; Zope, Sunil Sudhakar; Narawade, Krishna Baban; Thanedar, Amit Anant. A process for the preparation of eslicarbazepine. Assignee Glenmark Generics Limited, India. WO 2012156987. (2012).

Eslicarbazepine acetate - Synthetic Route 5

Eslicarbazepine acetate route05

Synthetic reference

Kandula, Mahesh. Preparation of dibenzocycloheptenecarboxamide compounds and methods for the treatment of neurological disorders. Assignee Cellix Bio Private Limited, India. US 20160122332. (2016).

Eslicarbazepine acetate - Synthetic Route 6

Eslicarbazepine acetate route06

Synthetic reference

Reddy, Manne Satyanarayana; Eswaraiah, Sajja; Reddy, Bairy Kondal. An improved process for the preparation of (S)-10-acetoxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide. Assignee MSN Laboratories Limited, India. IN 2010CH01229. (2012).

Eslicarbazepine acetate - Synthetic Route 7

Eslicarbazepine acetate route07

Synthetic reference

Xu, Ziao; Zhao, Yonghai; Li, Xiaoxiang. Method for synthesis of eslicarbazepine acetate. Assignee Anhui New Star Pharmaceutical Development Co., Ltd., Peop. Rep. China; Hefei City Xinxing Pharmaceutical Chemical Co., Ltd. CN 105130899. (2015).