Fingolimod

CAT#: H584406

CAS#: 162359-55-9

Description: Fingolimod is used to treat multiple sclerosis, and has antineoplastic activity.

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Synthetic Routes

Fingolimod - Synthetic Route 1

Fingolimod route01

Synthetic reference

Shaikh, Rizwan S.; Schilson, Stefanie S.; Wagner, Stefan; Hermann, Sven; Keul, Petra; Levkau, Bodo; Schaefers, Michael; Haufe, Guenter. Synthesis and Evaluation of Fluorinated Fingolimod (FTY720) Analogues for Sphingosine-1-Phosphate Receptor Molecular Imaging by Positron Emission Tomography. Journal of Medicinal Chemistry. Volume 58. Issue 8. Pages 3471-3484. Journal; Online Computer File. (2015).

Fingolimod - Synthetic Route 2

Fingolimod route02

Synthetic reference

Calleja, Jonas; Pla, Daniel; Gorman, Timothy W.; Domingo, Victoriano; Haffemayer, Benjamin; Gaunt, Matthew J. A steric tethering approach enables palladium-catalysed C-H activation of primary amino alcohols. Nature Chemistry. Volume 7. Issue 12. Pages 1009-1016. Journal; Online Computer File. (2015).

Fingolimod - Synthetic Route 3

Fingolimod route03

Synthetic reference

Chen, Yao; Wang, Xiaokui; Hu, Chun; Li, Song. Synthesis of a new immunosuppressant 2-amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride (FTY720). Zhongguo Yaowu Huaxue Zazhi. Volume 19. Issue 4. Pages 257-260. Journal. (2009).

Fingolimod - Synthetic Route 4

Fingolimod route04

Synthetic reference

Maruthi, Raju N.; Venkateswara, Rao B.; Siddaiah, V. Efficient method for the synthesis of fingolimod and impurities. Pharma Chemica. Volume 9. Issue 14. Pages 36-40. Journal; Online Computer File. (2017).

Fingolimod - Synthetic Route 5

Fingolimod route05

Synthetic reference

Kim, Sanghee; Lee, Hyeseung; Lee, Minhee; Lee, Taeho. Efficient synthesis of the immunosuppressive agent FTY720. Synthesis. Issue 5. Pages 753-755. Journal. (2006).

Fingolimod - Synthetic Route 6

Fingolimod route06

Synthetic reference

Fingolimod - Synthetic Route 7

Fingolimod route07

Synthetic reference

Mishina, Tadashi; Ohara, Toshiyuki; Adachi, Kunitomo. Preparation of 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol as immunosuppressive agents. Assignee Yoshitomi Pharmaceutical Industries, Ltd., Japan; Tanabe Seiyaku Co., Ltd. JP 11310556. (1999).

Fingolimod - Synthetic Route 8

Fingolimod route08

Synthetic reference

Gharpure, Milind; Narawade, Krishna; Chand, Prem. Preparation of fingolimod free of the ortho isomer. Assignee Glenmark Generics Limited, India. IN 2012MU00254. (2013).