Caspofungin Acetate

CAT#: H314268

CAS#: 179463-17-3

Description: Caspofungin acetate is a lipopeptide antifungal drug. It is a member of a new class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. Caspofungin acetate for injection was originally approved by FDA in USA, and the EMEA in Europe, in 2001.

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Synthetic Routes

Caspofungin Acetate - Synthetic Route 1

Caspofungin Acetate route01

Synthetic reference

Leonard, William R., Jr.; Belyk, Kevin M.; Conlon, David A.; Bender, Dean R.; DiMichele, Lisa M.; Liu, Ji; Hughes, David L. Synthesis of the Antifungal β-1,3-Glucan Synthase Inhibitor CANCIDAS (Caspofungin Acetate) from Pneumocandin B0. Journal of Organic Chemistry. Process Research Department. Merck Research Laboratories. Rahway, USA 07065-0900. Volume 72. Issue 7. Pages 2335-2343. 2007

Caspofungin Acetate - Synthetic Route 2

Caspofungin Acetate route02

Synthetic reference

Okabe, Hiroyuki; Naraoka, Asuka; Isogawa, Takahiro; Oishi, Shunsuke; Naka, Hiroshi. Acceptor-Controlled Transfer Dehydration of Amides to Nitriles. Organic Letters. Graduate School of Science. Nagoya University. Chikusa, Nagoya, Japan 464-8602. Volume 21. Issue 12. Pages 4767-477 0. 2019

Caspofungin Acetate - Synthetic Route 3

Caspofungin Acetate route03

Synthetic reference

Ludescher, Johannes; Macher, Ingolf; Storm, Ole; Bertel, Stephan. Process and intermediates for the synthesis of aza cyclohexapeptides, especially caspofungin from pneumocandin B0. Assignee Sandoz AG, Switz. EP 1785432. 2007

Caspofungin Acetate - Synthetic Route 4

Caspofungin Acetate route04

Synthetic reference

Lee, Kwang-Chung; Tung, Yen-Shih; Fang, Hao-Ling. Process for preparation of caspofungin acetate. US 20100168415. 2010

Caspofungin Acetate - Synthetic Route 5

Caspofungin Acetate route05

Synthetic reference

Kothakonda, Kiran Kumar; Sripathi, Sandeep Rao Sanjivirao; Venkata, Srinivas Pullela; George, Lijo; Prasad, Anegondi Sreenivasa. Process for preparation of caspofungin acetate and intermediates from pneu mocandin B0. Assignee Biocon Limited, India. WO 2012093293. 2012

Caspofungin Acetate - Synthetic Route 6

Caspofungin Acetate route06

Synthetic reference

Belyk, Kevin M.; Bender, Dean R.; Black, Regina M.; Hughes, David L.; Leonard, William. Process for preparing pneumocandin-derived aza cyclohexapeptides via carbonyl reduction of the 3-hydroxy-L-glutaminyl group and stereoselective phenylsulfenylation/amination of the 4,5-dihydroxy-L-ornithyl group. Assignee Merck and Co., Inc., USA. US 5552521. 1996

Caspofungin Acetate - Synthetic Route 7

Caspofungin Acetate route07

Synthetic reference

Leonard, William; Belyk, Kevin M. Process for preparing certain aza cyclohexapeptides. Assignee Merck and Co., Inc., USA. US 5936062. 1999

Caspofungin Acetate - Synthetic Route 8

Caspofungin Acetate route08

Synthetic reference

Eidelman, Chaim; Tovi, Avi; Alon, Hagai; Pirogov, Vitali; Gelfond, Adelina; Nemethne Racz, Csilla; Korodi, Ferenc; Kovacs, Piroska; Gold, Amir; Rudinski, Alexander. Processes for preparing high purity aza cyclohexapeptides. Assignee Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag, Hung.; Teva Pharmaceuticals USA , Inc. WO 2010008493. 2010