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Cefditoren Pivoxil

CAT#: H319527

CAS#: 117467-28-4

Description: Cefditoren Pivoxil is a semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic with bactericidal activity. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren, an active aminothiazolyl cephalosporin. Cefditoren inactivates penicillin binding proteins (PBPs) thereby interfering with peptidoglycan synthesis and inhibiting bacterial cell wall synthesis.

Synthetic Routes

Cefditoren Pivoxil - Synthetic Route 1

Synthetic reference

Sakagami, Kenji; Atsumi, Kunio; Yamamoto, Yuichi; Tamura, Atsuhi; Yoshida, Takashi; Nishihata, Ken; Fukatsu, Shunzo. Synthesis and oral activity of pivaloyloxymethyl 7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3(Z)-(4-methylthiazol-5-yl)vinyl-3-cephem-4-carboxylate (ME1207) and its related compound. Chemical & Pharmaceutical Bulletin. Pharm. Res. Cent. Meiji Seika Kaisha, Ltd. Yokohama, Japan 222. Volume 39. Issue 9. Pages 2433-6. 1991

Cefditoren Pivoxil - Synthetic Route 2

Synthetic reference

Godbole, Himanshu Madhav; Mehare, Kishor Gulabrao; Mane, Narendra Dattatraya; Dubey, Rajeev Ramachandra; Zadbuke, Swapnil Ajit. An improved process for the preparation of 7-amino-3-(4-methylthiazol-5-yl) vinyl-3-cephem-4-carboxylic acid. Assignee Lupin Limited, India. IN 2010KO00923. 2012

Cefditoren Pivoxil - Synthetic Route 3

Synthetic reference

Prabhat, Kumar Sahoo; Vempali, Anandam; Sundaravadivelan, Sivakumaran; Praveen, Nagesh Ganesh; Vittal, Manikrao Waghdare; Pandurang, Balawant Deshpande; Parven, Kumar Luthra; Pratik, Ramesh Sathe. An improved process for the preparation of cefditoren and its intermediates. Assignee Orchid Chemicals & Pharmaceuticals Ltd., India. WO 2005003141. 2005

Cefditoren Pivoxil - Synthetic Route 4

Synthetic reference

Sa, Yingfu; Ren, Bingjun. Preparation of cephalothin type antibiotics. Assignee Zhejiang Zhenyuan Pharmaceutical Co., Ltd., Peop. Rep. China; Shanghai Luwan District Guanglu Technology and Trade Co., Ltd. CN 1763046. 2006

Cefditoren Pivoxil - Synthetic Route 5

Synthetic reference

Kumar, Sahoo Prabhat; Ramesh, Manepalli; Kumar, Tiwari Anoop; Kumar, Pathak Dharmendra; Rao, Bagadi Ramachandra. Process for the purification of cefditoren sodium. Assignee Nectar Lifesciences Ltd., India. IN 2011DE01224. 2013process for the preparation of cefditoren an its intermediates

Cefditoren Pivoxil - Synthetic Route 6

Synthetic reference

Jin, Lianming; He, Jian; Men, Wanhui; Zou, Jing. Process for preparation of cefditoren pivoxil. Assignee Hubei Lingsheng Pharmaceuticals Co., Ltd., Peop. Rep. China; Wuhan Institute of Technology. CN 109369681. 2019

Cefditoren Pivoxil - Synthetic Route 7

Synthetic reference

Wakui, Atsushi; Oohara, Nobuhiko; Takubo, Yosuke; Matsumoto, Nobuo. Process for preparation of cephalosporin derivative. Assignee Nippon Chemical Industrial Co., Ltd., Japan. WO 2011093294. 2011

Cefditoren Pivoxil - Synthetic Route 8

Synthetic reference

Liu, Zhenteng; Chen, Yu; Zhang, Jinbao; Wang, Ping. Preparation method of cefditoren pivoxil for treating infections due to gram-positive bacteria and gram-negative bacteria from 7-ACA as starting raw material. Assignee Shandong Yuxin Pharmaceutical Co., Ltd., Peop. Rep. China. CN 108084212cess. 2018

Cefditoren Pivoxil - Synthetic Route 9

Synthetic reference

Prasad, Mohan; Kumar, Yatendra; Singh, Kaptan; Prasad, Ashok; Richhariya, Santosh. Process for selective preparation of Z-isomer of cefditoren and pharmaceutically acceptable salts and esters thereof. Assignee Ranbaxy Laboratories Limited, India. WO 2005016936. 2005

Cefditoren Pivoxil - Synthetic Route 10

Synthetic reference

Sahoo, Prabhat Kumar; Sunderavadivelan, Sivakumaran; Vempelli, Anandam; Kumar, Udayampalayam Palanisamy Senthil. Improved process for the preparation of cephalosporin antibiotics. Assignee Orchid Chemicals & Pharmaceuticals Ltd., India. IN 2005CH00560. 2007