Maraviroc

CAT#: H318173

CAS#: 376348-65-1

Description: Maraviroc is an antiviral, potent, non-competitive CKR-5 receptor antagonist that inhibits binding of HIV viral coat protein gp120. Maraviroc inhibits MIP-1β-stimulated γ-S-GTP binding to HEK-293 cell membranes, indicating its ability to inhibit chemokine-dependent stimulation of GDP-GTP exchange at the CKR-5/G protein complex. Maraviroc also inhibits the downstream event of chemokine-induced intracellular calcium redistribution.

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Synthetic Routes

Maraviroc - Synthetic Route 1

Maraviroc route01

Synthetic reference

Lou, Sha; Moquist, Philip N.; Schaus, Scott E. Asymmetric Allylboration of Acyl Imines Catalyzed by Chiral Diols. Journal of the American Chemical Society. Volume 129. Issue 49. Pages 15398-15404. 2007.

Maraviroc - Synthetic Route 2

Maraviroc route02

Synthetic reference

Haycock-Lewandowski, Sarah J.; Wilder, Alexander; Ahman, Jens. Development of a Bulk Enabling Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist. Organic Process Research & Development. Volume 12. Issue 6. Pages 1094-1103. 2008.

Maraviroc - Synthetic Route 3

Maraviroc route03

Synthetic reference

Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew. Initial synthesis of UK-427,857 (Maraviroc). Tetrahedron Letters. Volume 46. Issue 30. Pages 5005-5007. 2005.

Maraviroc - Synthetic Route 4

Maraviroc route04

Synthetic reference

Zhao, Gui-Ling; Lin, Shuangzheng; Korotvicka, Ales; Deiana, Luca; Kullberg, Martin; Cordova, Armando. Asymmetric Synthesis of Maraviroc (UK-427,857). Advanced Synthesis & Catalysis. Volume 352. Issue 13. Pages 2291-2298. 2010.

Maraviroc - Synthetic Route 5

Maraviroc route05

Synthetic reference

Ahman, Jens; Birch, Melissa; Haycock-Lewandowski, Sarah J.; Long, James; Wilder, Alexander. Process Research and Scale-up of a Commercializable Route to Maraviroc (UK-427,857), a CCR-5 Receptor Antagonist. Organic Process Research & Development. Volume 12. Issue 6. Pages 1104-1113. 2008.

Maraviroc - Synthetic Route 6

Maraviroc route06

Synthetic reference

Perros, Manoussos; Price, David Anthony; Stammen, Blanda Luzia Christa; Wood, Anthony. Preparation of therapeutic tropane derivatives. Assignee Pfizer Limited, UK; Pfizer Inc. WO 2001090106. (2001).

Maraviroc - Synthetic Route 7

Maraviroc route07

Synthetic reference

Li, Dongmei; Tan, Yu; Peng, Lei; Li, Shan; Zhang, Nan; Liu, Yidong; Yan, Hailong. Asymmetric Mannich Reaction and Construction of Axially Chiral Sulfone-Containing Styrenes in One Pot from α-Amido Sulfones Based on the Waste-Reuse Strategy. Organic Letters. Volume 20. Issue 16. Pages 4959-4963. 2018.

Maraviroc - Synthetic Route 8

Maraviroc route08

Synthetic reference

Olson, William C.; Ketas, Thomas J.; Marozsan, Andre. Methods using humanized and monoclonal antibodies for inhibiting infection by diverse subtypes of drug-resistant HIV-1. Assignee Progenics Pharmaceuticals, Inc., USA. WO 2009134401. (2009).

Maraviroc - Synthetic Route 9

Maraviroc route09

Synthetic reference

Zhou, Shengbin; Wang, Shuni; Wang, Jiang; Nian, Yong; Peng, Panfeng; Soloshonok, Vadim A.; Liu, Hong. Configurationally stable (S)- and (R)-α-methylproline-derived ligands for the direct chemical resolution of free unprotected β3-amino acids. European Journal of Organic Chemistry. Volume 2018. Issue 15. Pages 1821-1832. 2018.

Maraviroc - Synthetic Route 10

Maraviroc route010

Synthetic reference

Zhu, Yijun; Li, Hongyan; Lin, Kuaile; Wang, Bing; Zhou, Weicheng. A novel and efficient asymmetric synthesis of anti-HIV drug maraviroc. Synthetic Communications. Volume 49. Issue 13. Pages 1721-1728. 2019.