Milnacipran (HCl)

CAT#: H318273

CAS#: 92623-85-3 / 101152-94-7

Description: Milnacipran is a serotonin–norepinephrine reuptake inhibitor (SNRI) used in the clinical treatment of fibromyalgia. It is not approved for the clinical treatment of major depressive disorder in the USA, but it is in other countries.

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Synthetic Routes

Milnacipran (HCl) - Synthetic Route 1

Milnacipran (HCl) route01

Synthetic reference

Coelho, Pedro S.; Brustad, Eric M.; Arnold, Frances H.; Wang, Zhan; Lewis, Jared C. In vivo and in vitro olefin cyclopropanation catalyzed by engineered and chimeric heme enzymes. Assignee California Institute of Technology, USA. WO 2014058744. (2014).

Milnacipran (HCl) - Synthetic Route 2

Milnacipran (HCl) route02

Synthetic reference

Bonnaud, Bernard; Cousse, Henri; Mouzin, Gilbert; Briley, Mike; Stenger, Antoine; Fauran, Francois; Couzinier, Jean Pierre. 1-Aryl-2-(aminomethyl)cyclopropanecarboxylic acid derivatives. A new series of potential antidepressants. Journal of Medicinal Chemistry. Volume 30. Issue 2. Pages 318-25. 1987.

Milnacipran (HCl) - Synthetic Route 3

Milnacipran (HCl) route03

Synthetic reference

Rajan, Srinivasan Thirumalai; Satyanarayana, Revu. Improved process for the preparation of (Z)-2-aminomethyl-1-phenyl-N,N-diethylcyclopropanecarboxamide. Assignee MSN Laboratories Limited, India. IN 2010CH02958. (2012).

Milnacipran (HCl) - Synthetic Route 4

Milnacipran (HCl) route04

Synthetic reference

Xu, Guanbing; Shen, Wenjing; Qin, Xinrong; Shen, Gang; Jing, Yuqian; Shi, Yuming; Chen, Wen. Process for preparation of Milnacipran hydrochloride intermediate. Assignee Shanghai Modern Pharmaceutical Co., Ltd., Peop. Rep. China. CN 103613513. (2014).

Milnacipran (HCl) - Synthetic Route 5

Milnacipran (HCl) route05

Synthetic reference

Gaddam, Venugopal Reddy; Varada, Jayakrishna; Cheluvaraju; Gajula, Madhusudana Rao; Rastogi, Pramod Kumar. An improved process for the preparation of 1-aryl-2-aminomethylcyclopropanecarboxamide derivatives, their isomers and salts. Assignee Micro Labs Limited, India. IN 2012CH02752. (2016).

Milnacipran (HCl) - Synthetic Route 6

Milnacipran (HCl) route06

Synthetic reference

Jambukar, Nagambar Genuji; Gharpure, Milind; Sinare, Sudam Nanabhau; Thombre, Pravin Chhaburao; Khan, Mubeen Ahmed. Process for preparation of milnacipran intermediate and its use in preparation of pure milnacipran. Assignee Glenmark Generics Limited, India. WO 2011158249. (2011).

Milnacipran (HCl) - Synthetic Route 7

Milnacipran (HCl) route07

Synthetic reference

Wang, Xiaoqin; Xu, Peng; Gu, Junlin; Yang, Liping. Synthesis of Milnacipran Hydrochloride Dextroisomer. Zhongguo Yiyao Gongye Zazhi. Volume 35. Issue 5. Pages 259-260. 2004.

Milnacipran (HCl) - Synthetic Route 8

Milnacipran (HCl) route08

Synthetic reference

Lee, In-Hui; Lee, Jong-Ok; Moon, Byeong-Heon; Lee, Ho-Yun; Hahn, Young Kwon; Kim, Chang-Hwan. Preparation of cis-milnacipran hydrochloride. Assignee Ahn-Gook Pharmaceutical Co., Ltd., S. Korea. JP 2007023005. (2007).

Milnacipran (HCl) - Synthetic Route 9

Milnacipran (HCl) route09

Synthetic reference

Arava, Glory; Venkatasubbanaidu, N. Efficient synthesis of milnacipran hydrochloride with atom economy approach. Heterocyclic Letters. Volume 6. Issue 3. Pages 471-477. 2016.

Milnacipran (HCl) - Synthetic Route 10

Milnacipran (HCl) route010

Synthetic reference

Niimoto, Yoshihide; Kumazawa, Hiroharu; Kawami, Koh. Process for producing cis-1-phenyl-1-(N,N-diethylaminocarbonyl)-2-phthalimidomethylcyclopropane. Assignee Sumitomo Chemical Company, Limited, Japan. WO 2006080555. (2006).