Cilostazol

CAT#: H317527

CAS#: 73963-72-1


Description: Cilostazol is a quinolinone-derivative medication used in the alleviation of the symptom of claudication in individuals with peripheral vascular disease. Cilostazol is a phosphodiesterase inhibitor with therapeutic focus on cyclic adenosine monophosphate (cAMP). It inhibits platelet aggregation and is a direct arterial vasodilator. Its main effects are dilation of the arteries supplying blood to the legs and decreasing platelet coagulation. It is under the trade name Pletal.

img

Synthetic Routes

Cilostazol - Synthetic Route 1

Cilostazol route01

Synthetic reference

Chandgude, Ajay L.; Doemling, Alexander. Convergent Three-Component Tetrazole Synthesis. European Journal of Organic Chemistry. Department of Drug Design. University of Groningen. Groningen, Neth. 9713 AV. Volume 2016. Issue 14.Pages 2383-2387. 2016

Cilostazol - Synthetic Route 2

Cilostazol route02

Synthetic reference

Nishi, Takao; Tabusa, Fujio; Tanaka, Tatsuyoshi; Shimizu, Takefumi; Kanbe, Toshimi; Kimura, Yukio; Nakagawa, Kazuyuki. Studies on 2-oxoquinoline derivatives as blood platelet aggregation inhibitors. II. 6-[3-(1-Cyclohexyl-5-tetrazolyl)propoxy]-1,2-dihydro-2-oxoquinoline and related compounds. Chemical & Pharmaceutical Bulletin. Tokushima Res. Inst. Otsuka Pharm. Co., Ltd. Tokushima, Japan 771-01. Volume 31. Issue 4. Pages 1151-7. 1983

Cilostazol - Synthetic Route 3

Cilostazol route03

Synthetic reference

Aki, Shinji; Nishi, Takao; Minamikawa, Jun-ichi. An efficient lutidine-assisted etherification of phenols with alkyl chloride in water. Chemistry Letters. Process Research Laboratory, 2nd Tokushima Factory. Otsuka Pharmaceutical Co., Ltd. Tokushima, Japan 771-0182. Volume 33. Issue 7. Pages 940-941. 2004

Cilostazol - Synthetic Route 4

Cilostazol route04

Synthetic reference

Zhao, Hailong; Sheng, Jinhuo; Zhang, Xiaowei; Zhao, Binfeng; Qian, Zhiying; Chen, Xiaohong. Process for preparation of cilostazol. Assignee Zhejiang Kinglyuan Pharmaceutical Co., Ltd., Peop. Rep. China. CN 105111190. 2015

Cilostazol - Synthetic Route 5

Cilostazol route05

Synthetic reference

Kankan, R. N.; Rao, D. R.; Narayan, B. M. Preparation of cilostazol. Assignee Cipla Limited, India. IN 2003MU00444. 2005

Cilostazol - Synthetic Route 6

Cilostazol route06

Synthetic reference

Zhang, Yun. Method for manufacturing Cilostazol. CN 104744436. 2015

Cilostazol - Synthetic Route 7

Cilostazol route07

Synthetic reference

Mendelovichi, Marioara; Finkelstein, Nina; Pilarksi, Gideon. Preparation of cilostazol. Assignee Teva Pharmaceutical Industries Ltd., Israel; Teva Pharmaceuticals USA, Inc. WO 2002014283. 2002