Nebivolol

CAT#: H318353

CAS#: 118457-14-0

Description: Nebivolol is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and, in Europe, also for left ventricular failure. It is highly cardioselective under certain circumstances.

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Synthetic Routes

Nebivolol - Synthetic Route 1

Nebivolol route01

Synthetic reference

Sheth, Rakesh; Attanti, Srinivasarao Veeravenkata; Patel, Hasmukh Mathurbhai; Gupta, Vinodkumar; Nadkarni, Sunil Sadanand. Process for preparation of Nebivolol from 6-fluoro-3,4-dihydro-α-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol and 6-fluoro-3,4-dihydro-2-oxiranyl-2H-benzopyran. Assignee Torrent Pharmaceuticals Limited, India. WO 2006025070. (2006).

Nebivolol - Synthetic Route 2

Nebivolol route02

Synthetic reference

Trinka, Peter; Reiter, Jozsef; Berecz, Gabor; Simig, Gyula. New process for the preparation of racemic ([2s[2r*[r[r*]]]] and ([2r[2s*[s[s*]]]]-(±)- α,α' -[imino-bis(methylene)]bis[6-fluoro-chroman-2-methanol] and its pure [2s[2r*[r[r*]&. Assignee Egis Gyogyszergyar Rt., Hung. WO 2004041805. (2004).

Nebivolol - Synthetic Route 3

Nebivolol route03

Synthetic reference

Bartoli, Sandra; Cipollone, Amalia; Fattori, Daniela. Process for the preparation of Nebivolol. Assignee Menarini International Operations Luxembourg S.A., Luxembourg. US 20130274486. (2013).

Nebivolol - Synthetic Route 4

Nebivolol route04

Synthetic reference

Noe, Christian R.; Jasic, Muhamed; Kollmann, Hermann; Lachmann, Bodo. Process for preparation of Nebivolol using 6-fluoro-3,4-dihydrobenzopyran-2-carboxaldehyde cyanohydrins. Assignee Pharmacon - Forschung und Beratung G.m.b.H., Austria. WO 2007009143. (2007).

Nebivolol - Synthetic Route 5

Nebivolol route05

Synthetic reference

Du, Xiaochun; Yan, Jun. A method for preparing nebivolol hydrochloride. Assignee Chengdu Kanghong Pharmaceutical Group Co., Ltd., Peop. Rep. China. CN 102344431. (2012).

Nebivolol - Synthetic Route 6

Nebivolol route06

Synthetic reference

Kumar, Ashok; Buchi, Reddy Reguri; More, Kishor Ramdas; Chidurala, Rajashekhar; Gawade, Sanjay Pandurang; Chavan, Navanath Maruti; Choudhari, Shailesh Mallikarjun; Sadakal, Jeevan Bharat; Malekar, Sachin; Patil, Yuvaraj. Process for preparation of nebivolol and it's salts. Assignee Ipca Laboratories Limited, India. WO 2016185492. (2016).

Nebivolol - Synthetic Route 7

Nebivolol route07

Synthetic reference

Clavel, Alexandre; Freifeld, Ilia; Jas, Gerhard; Kesseler, Kurt. A new method for producing nebivolol hydrochloride of high purity. Assignee Corden Pharma International GmbH, Germany. WO 2015121452. (2015).

Nebivolol - Synthetic Route 8

Nebivolol route08

Synthetic reference

Goud, Thirumani Vengateshwar; Unni, Santhosh; Kathiravan, Pusali Rathinasabapathy; Siripragada, Mahender Rao. A process for the preparation of fluorodihydrobenzopyrancarboxaldehyde as a key intermediate of nebivolol. Assignee Orchid Chemicals & Pharmaceuticals Ltd., India. IN 2008CH02703. (2011).