Conivaptan Hydrochloride

CAT#: H526637

CAS#: 168626-94-6

Description: Conivaptan hydrochloride is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).

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Synthetic Routes

Conivaptan Hydrochloride - Synthetic Route 1

Conivaptan Hydrochloride route01

Synthetic reference

Tsunoda, Takashi; Yamazaki, Atsuki; Iwamoto, Hidenori; Sakamoto, Shuichi. Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: an Arginine Vasopressin Antagonist. Organic Process Research & Development. Chemical Technology Labs. Yamanouchi Pharmaceutical Co., Ltd. Takahagi-shi, Ibaraki, Japan 318-0001. Volume 7. Issue 6. Pages 883-887. 2003

Conivaptan Hydrochloride - Synthetic Route 2

Conivaptan Hydrochloride route02

Synthetic reference

Yu, Defeng; Sun, Yunbei; Kong, Fangang. Preparation of Conivaptan hydrochloride with aniline as starting material. Assignee Shandong Luoxin Pharmaceutical Group Co., Ltd., Peop. Rep. China. CN 106317060. 2017

Conivaptan Hydrochloride - Synthetic Route 3

Conivaptan Hydrochloride route03

Synthetic reference

Lixin, Juanzi; Li, Jianzhi; Ma, Xilai; Chi, Wangzhou; Sun, Li; Liu, Hai; Hu, Xuhua; Zheng, Xiaoli; Zhai, Zhijun; Li, Jianxun. Process for preparation of Vaprisol. Assignee Shanghai Tianci International Pharmaceutical Co., Ltd., Peop. Rep. China. CN 105153168. 2015