Pazopanib

CAT#: H202161

CAS#: 444731-52-6

Description: Pazopanib is an approved drug, is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated.

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Synthetic Routes

Pazopanib - Synthetic Route 1

Pazopanib route01

Synthetic reference

Boloor, Amogh; Cheung, Mui; Davis, Ronda; Harris, Philip Anthony; Hinkle, Kevin; Mook, Robert Anthony; Stafford, Jeffery Alan; Veal, James Martin. Preparation of pyrimidinamines as angiogenesis modulators. Assignee Glaxo Group Limited, UK. WO 2002059110. (2002).

Pazopanib - Synthetic Route 2

Pazopanib route02

Synthetic reference

Jia, Yuping; Zhang, Jian; Feng, Jinhong; Xu, Fuming; Pan, Huili; Xu, Wenfang. Design, Synthesis and Biological Evaluation of Pazopanib Derivatives as Antitumor Agents. Chemical Biology & Drug Design. Volume 83. Issue 3. Pages 306-316. 2014.

Pazopanib - Synthetic Route 3

Pazopanib route03

Synthetic reference

Mei, Yi Cheng; Yang, Bao Wei; Chen, Wei; Huang, Dan Dan; Li, Ying; Deng, Xin; Liu, Bao Ming; Wang, Jing Jie; Qian, Hai; Huang, Wen Long. A novel practical synthesis of pazopanib: an anticancer drug. Letters in Organic Chemistry. Volume 9. Issue 4. Pages 276-279. 2012.

Pazopanib - Synthetic Route 4

Pazopanib route04

Synthetic reference

Brigandi, Richard Anthony; Levick, Mark; Miller, William Henry. method for treatment of an ocular neovascular disorder by administration of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide and (S)-3-oxo-8-[3-(pyridin-2-ylamino)-1-propyloxy]-2-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-2-benzazepine-4-acetic acid. Assignee SmithKline Beecham Corp., USA. WO 2007064752. (2007).

Pazopanib - Synthetic Route 5

Pazopanib route05

Synthetic reference

Liu, Haidong; Ji, Min; Zong, Xi; Wang, Dongdong; Yang, Su; Wan, Guangpeng; Yu, Wenyuan; Hu, Haiyan; Zhang, Ying. Preparation of pazopanib and intermediate thereof. Assignee Suzhou Southeast Pharmaceuticals Co., Ltd., Peop. Rep. China. CN 107721989. (2018).

Pazopanib - Synthetic Route 6

Pazopanib route06

Synthetic reference

Nagaraju, Manne; Reddy, Baddam Sudhakar; Rao, Anthyakula Bhaskar; Kumar, Doniparthi Kiran; Kumar, Kolla Naveen; Mohan, Moovendan. A process for the preparation of pazopanib. Assignee Dr. Reddy's Laboratories Limited, India; Dr. Reddy's Laboratories Inc. IN 2011CH02505. (2013).