Darifenacin Hydrobromide

CAT#: H317583

CAS#: 133099-07-7

Description: Darifenacin, also known as UK-88525, is a medication used to treat urinary incontinence. Darifenacin works by blocking the M3 muscarinic acetylcholine receptor, which is primarily responsible for bladder muscle contractions. It thereby decreases the urgency to urinate.

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Synthetic Routes

Darifenacin Hydrobromide - Synthetic Route 1

Darifenacin Hydrobromide route01

Synthetic reference

Gao, Juan; Zang, Hengchang. Synthesis method of darifenacin hydrobromide. Qilu Yaoshi. School of Pharmaceutical Sciences. Shandong University. Jinan, Shandong Province, Peop. Rep. China 255012. Volume 31. Issue 2. Pages 68-69, 77. 2012

Darifenacin Hydrobromide - Synthetic Route 2

Darifenacin Hydrobromide route02

Synthetic reference

Liu, Changhuan; Yu, Xiong; Yuan, Zhedong. Synthesis of (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide (darifenacin hydrobromide). Zhongguo Yiyao Gongye Zazhi. Shanghai Institute of Pharmaceutical Industry. Shanghai, Peop. Rep. China 200437. Volume 38. Issue 12. Pages 825-827. 2007

Darifenacin Hydrobromide - Synthetic Route 3

Darifenacin Hydrobromide route03

Synthetic reference

Lin, Rong; Deng, Qi-hua; Zhou, Mi; Li, Zi-cheng; Zeng, Guo-cheng. Study on the synthesis of (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)ethyl]-α,α-diphenyl-3-pyrrolidineacetamide hydrobromide (darifenacin hydrobromide). Huaxue Shijie. Department of Pharmaceutical and biological Engineering, College of Chemical Engineering. Sichuan University. Sichuan Chengdu, Peop. Rep. China 610065. Volume 50. Issue 2. Pages 100-103. 2009

Darifenacin Hydrobromide - Synthetic Route 4

Darifenacin Hydrobromide route04

Synthetic reference

Merli, Valeriano; Canavesi, Augusto; Daverio, Paola. Processes for preparing darifenacin hydrobromide. Assignee Teva Pharmaceutical Fine Chemicals S.r.l., Italy; Teva Pharmaceuticals USA, Inc. WO 2007076158. 2007

Darifenacin Hydrobromide - Synthetic Route 5

Darifenacin Hydrobromide route05

Synthetic reference

Katkam, Srinivas; Vaddadi, Pattabhiramayya; Sunkara, Vishnuvardhan; Muttavarapu, Muralimohan; Kulkarni, Lalitha Dattatray; Sagyam, Rajeshwar Reddy; Pitta, Jaya Prakash; Buchnikonda, Ravinder; Munagala, Sridhar. Process for preparation of darifenacin. Assignee Dr. Reddy's Laboratories Ltd., India; Dr. Reddy's Laboratories, Inc. WO 2008100651. 2008

Darifenacin Hydrobromide - Synthetic Route 6

Darifenacin Hydrobromide route06

Synthetic reference

Darifenacin Hydrobromide - Synthetic Route 7

Darifenacin Hydrobromide route07

Synthetic reference

Lorente Bonde-Larsen, Antonio; Rodriguez Lopez, Maria; Fernandez Sainz, Yolanda; Gutierrez Fuentes, Luis Gerardo. Process for preparation of 1,3-difunctionalized pyrrolidines from 3-hydroxypyrrolidines. Assignee Ragactives, S.L., Spain. EP 2236509. 2010